3VEH
Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT
Summary for 3VEH
Entry DOI | 10.2210/pdb3veh/pdb |
Related | 3RV6 3RV7 3RV8 3RV9 3ST6 |
Descriptor | Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, THIOCYANATE ION, ... (7 entities in total) |
Functional Keywords | structural genomics, tb structural genomics consortium, tbsgc, salicylate synthase, lyase, isomerase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 197094.78 |
Authors | Bulloch, E.M.,Chi, G.,Manos-Turvey, A.,Johnston, J.M.,Baker, E.N.,Payne, R.J.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-01-08, release date: 2012-06-13, Last modification date: 2024-02-28) |
Primary citation | Chi, G.,Manos-Turvey, A.,O'Connor, P.D.,Johnston, J.M.,Evans, G.L.,Baker, E.N.,Payne, R.J.,Lott, J.S.,Bulloch, E.M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51:4868-4879, 2012 Cited by PubMed: 22607697DOI: 10.1021/bi3002067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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