4FL6
Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
Summary for 4FL6
Entry DOI | 10.2210/pdb4fl6/pdb |
Descriptor | Lethal(3)malignant brain tumor-like protein 3, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}, UNKNOWN ATOM OR ION (3 entities in total) |
Functional Keywords | structural genomics consortium, sgc, chromatin modification, transcription repression, mbt repeat, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q96JM7 |
Total number of polymer chains | 2 |
Total formula weight | 78080.90 |
Authors | Zhong, N.,Tempel, W.,Ravichandran, M.,Dong, A.,Ingerman, L.A.,Graslund, S.,Frye, S.V.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-14, release date: 2012-06-27, Last modification date: 2023-09-13) |
Primary citation | James, L.I.,Barsyte-Lovejoy, D.,Zhong, N.,Krichevsky, L.,Korboukh, V.K.,Herold, J.M.,MacNevin, C.J.,Norris, J.L.,Sagum, C.A.,Tempel, W.,Marcon, E.,Guo, H.,Gao, C.,Huang, X.P.,Duan, S.,Emili, A.,Greenblatt, J.F.,Kireev, D.B.,Jin, J.,Janzen, W.P.,Brown, P.J.,Bedford, M.T.,Arrowsmith, C.H.,Frye, S.V. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat. Chem. Biol., 9:184-191, 2013 Cited by PubMed: 23292653DOI: 10.1038/nchembio.1157 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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