3OQ5
Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1
Summary for 3OQ5
Entry DOI | 10.2210/pdb3oq5/pdb |
Descriptor | Lethal(3)malignant brain tumor-like protein, Cellular tumor antigen p53 (3 entities in total) |
Functional Keywords | l(3)mbt-like protein, protein lysine methyltransferase; malignant brain tumor, chromatin regulator, dna-binding, metal-binding, nucleus, repressor, transcription regulation, zinc-finger, chromosomal protein, methylation, three-leaved beta-propeller, transcription, p53 |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9Y468 Cytoplasm: Q5U0E4 |
Total number of polymer chains | 5 |
Total formula weight | 119997.16 |
Authors | Roy, S.,West, L.E.,Weiner, K.L.,Hayashi, R.,Shi, X.,Appella, E.,Gozani, O.,Kutateladze, T. (deposition date: 2010-09-02, release date: 2010-09-22, Last modification date: 2023-09-06) |
Primary citation | West, L.E.,Roy, S.,Lachmi-Weiner, K.,Hayashi, R.,Shi, X.,Appella, E.,Kutateladze, T.G.,Gozani, O. The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression. J.Biol.Chem., 285:37725-37732, 2010 Cited by PubMed: 20870725DOI: 10.1074/jbc.M110.139527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5005 Å) |
Structure validation
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