6N1Z
 
 | | Importin-9 bound to H2A-H2B | | Descriptor: | Histone H2A, Histone H2B 1.1, Importin-9 | | Authors: | Tomchick, D.R, Chook, Y.M, Padavannil, A. | | Deposit date: | 2018-11-12 | | Release date: | 2019-03-20 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.
Elife, 8, 2019
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1IAL
 | | IMPORTIN ALPHA, MOUSE | | Descriptor: | IMPORTIN ALPHA | | Authors: | Kobe, B. | | Deposit date: | 1999-01-12 | | Release date: | 1999-06-15 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
Nat.Struct.Biol., 6, 1999
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8F2Q
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5XAH
 | | Crystal structure of human Importin4 | | Descriptor: | Importin-4 | | Authors: | Song, J.J, Yoon, J. | | Deposit date: | 2017-03-13 | | Release date: | 2018-02-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding
J. Mol. Biol., 430, 2018
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7RHT
 | | Importin alpha 7 delta IBB (KPNA6) | | Descriptor: | Importin subunit alpha-7 | | Authors: | Tsimbalyuk, S, Forwood, J.K. | | Deposit date: | 2021-07-18 | | Release date: | 2022-02-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 angstrom resolution.
Sci Rep, 12, 2022
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1O6O
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1O6P
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6P6A
 | | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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6P6E
 | | Structure of Mouse Importin alpha - PAC3 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, PAC3 NLS | | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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3Q5U
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1EJY
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1EJL
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5GXW
 | | Importin and NuMA complex | | Descriptor: | Importin subunit alpha-1, Peptide from Nuclear mitotic apparatus protein 1 | | Authors: | Chang, C.-C, Huang, T.-L, Hsia, K.-C. | | Deposit date: | 2016-09-20 | | Release date: | 2017-10-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | Regulation of mitotic spindle assembly factor NuMA by Importin-beta
J. Cell Biol., 216, 2017
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1GCJ
 | | N-TERMINAL FRAGMENT OF IMPORTIN-BETA | | Descriptor: | IMPORTIN BETA | | Authors: | Lee, S.J, Imamoto, N, Sakai, H, Nakagawa, A, Kose, S, Koike, M, Yamamoto, M, Kumasaka, T, Yoneda, Y, Tsukihara, T. | | Deposit date: | 2000-07-31 | | Release date: | 2000-10-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport.
J.Mol.Biol., 302, 2000
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1PJM
 | | Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | | Descriptor: | Importin alpha-2 subunit, Retinoblastoma-associated protein | | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | | Deposit date: | 2003-06-03 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
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4TNM
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4UAF
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4UAE
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4U5V
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.968 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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4U5N
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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4U5O
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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4UAD
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4U5L
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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4U5S
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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4U54
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-24 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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