PDB: 460 件ウェブページステータス検索Chemie searchBIRD

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1H23	Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution 分子名称: (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE 著者 Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.F, Pang, Y.P, Silman, I, Sussman, J.L. 登録日 2002-07-30 公開日 2002-12-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
1H22	Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution 分子名称: (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE 著者 Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.-F, Pang, Y.-P, Silman, I, Sussman, J.L. 登録日 2002-07-30 公開日 2002-12-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
1AX9	ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA 分子名称: ACETYLCHOLINESTERASE, EDROPHONIUM ION 著者 Raves, M.L, Ravelli, R.B.G, Sussman, J.L, Harel, M, Silman, I. 登録日 1997-11-03 公開日 1998-02-11 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Static Laue diffraction studies on acetylcholinesterase. Acta Crystallogr.,Sect.D, 54, 1998
2ACK	ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA 分子名称: ACETYLCHOLINESTERASE, EDROPHONIUM ION 著者 Raves, M.L, Sussman, J.L, Harel, M, Silman, I. 登録日 1997-10-29 公開日 1998-02-11 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Static Laue diffraction studies on acetylcholinesterase. Acta Crystallogr.,Sect.D, 54, 1998
1C2B	ELECTROPHORUS ELECTRICUS ACETYLCHOLINESTERASE 分子名称: ACETYLCHOLINESTERASE 著者 Bourne, Y, Marchot, P. 登録日 1999-07-26 公開日 1999-12-29 最終更新日 2021-06-02 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Conformational flexibility of the acetylcholinesterase tetramer suggested by x-ray crystallography. J.Biol.Chem., 274, 1999
1C2O	ELECTROPHORUS ELECTRICUS ACETYLCHOLINESTERASE 分子名称: ACETYLCHOLINESTERASE 著者 Bourne, Y, Marchot, P. 登録日 1999-07-26 公開日 2000-01-19 最終更新日 2021-06-02 実験手法 X-RAY DIFFRACTION (4.2 Å) 主引用文献 Conformational flexibility of the acetylcholinesterase tetramer suggested by x-ray crystallography. J.Biol.Chem., 274, 1999
3LII	Recombinant human acetylcholinesterase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, SULFATE ION 著者 Dvir, H, Rosenberry, T, Harel, M, Silman, I, Sussman, J. 登録日 2010-01-25 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Acetylcholinesterase: From 3D structure to function. Chem.Biol.Interact, 187, 2010
1OCE	ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH MF268 分子名称: ACETYLCHOLINESTERASE, CIS-2,6-DIMETHYLMORPHOLINOOCTYLCARBAMYLESEROLINE 著者 Bartolucci, C, Perola, E, Cellai, L, Brufani, M, Lamba, D. 登録日 1998-06-12 公開日 1999-05-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry, 38, 1999
1VOT	ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A 分子名称: ACETYLCHOLINESTERASE, Huperzine A 著者 Raves, M.L, Harel, M, Silman, I, Sussman, J.L. 登録日 1996-06-23 公開日 1997-06-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat.Struct.Biol., 4, 1997
5DTI	Crystal structure of mouse acetylcholinesterase 分子名称: Acetylcholinesterase 著者 Tran, T.H, Tong, L. 登録日 2015-09-18 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Chembiochem, 16, 2015
1MAH	FASCICULIN2-MOUSE ACETYLCHOLINESTERASE COMPLEX 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, FASCICULIN 2 著者 Bourne, Y, Taylor, P, Marchot, P. 登録日 1995-11-21 公開日 1996-04-03 最終更新日 2021-03-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex. Cell(Cambridge,Mass.), 83, 1995
4M0F	Structure of human acetylcholinesterase in complex with territrem B 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cheung, J, Gary, E.N, Shiomi, K, Rosenberry, T.L. 登録日 2013-08-01 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Med Chem Lett, 4, 2013
4M0E	Structure of human acetylcholinesterase in complex with dihydrotanshinone I 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cheung, J, Gary, E.N, Shiomi, K, Rosenberry, T.L. 登録日 2013-08-01 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Med Chem Lett, 4, 2013
5NAU	Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like compound 20 分子名称: (2~{E})-5-methoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one, Acetylcholinesterase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Caliandro, R, Pesaresi, A, Lamba, D. 登録日 2017-02-28 公開日 2018-05-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. J Enzyme Inhib Med Chem, 33, 2018
5NAP	Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17 分子名称: (2~{E})-5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one, Acetylcholinesterase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Caliandro, R, Pesaresi, A, Lamba, D. 登録日 2017-02-28 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. J Enzyme Inhib Med Chem, 33, 2018
5OV9	Crystal structure of Acetylcholinesterase in complex with Crystal Violet 分子名称: 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, 2-(2-METHOXYETHOXY)ETHANOL, ... 著者 Allgardsson, A, Andersson, C.D, Akfur, C, Worek, F, Linusson, A, Ekstrom, F. 登録日 2017-08-28 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules, 22, 2017
2J3Q	Torpedo acetylcholinesterase complexed with fluorophore thioflavin T 分子名称: 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Harel, M, Cusack, B, Johnson, J.L, Silman, I, Sussman, J.L, Rosenberry, T.L. 登録日 2006-08-23 公開日 2007-09-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. J. Am. Chem. Soc., 130, 2008
2J4F	Torpedo acetylcholinesterase - Hg heavy-atom derivative 分子名称: ACETYLCHOLINESTERASE, MERCURY (II) ION 著者 Kreimer, D.I, Dolginova, E.A, Raves, M, Sussman, J.L, Silman, I, Weiner, L. 登録日 2006-08-30 公開日 2006-09-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A Metastable State of Torpedo Californica Acetylcholinesterase Generated by Modification with Organomercurials Biochemistry, 33, 1994
2JGE	Crystal structure of mouse acetylcholinesterase inhibited by non-aged methamidophos 分子名称: ACETYLCHOLINESTERASE, HEXAETHYLENE GLYCOL, TRIETHYLENE GLYCOL 著者 Hornberg, A, Tunemalm, A.-K, Ekstrom, F. 登録日 2007-02-13 公開日 2007-04-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of Acetylcholinesterase in Complex with Organophosphorus Compounds Suggest that the Acyl Pocket Modulates the Aging Reaction by Precluding the Formation of the Trigonal Bipyramidal Transition State. Biochemistry, 46, 2007
1ACL	QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE 分子名称: ACETYLCHOLINESTERASE, DECAMETHONIUM ION 著者 Sussman, J.L, Harel, M, Silman, I. 登録日 1993-08-18 公開日 1994-08-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc.Natl.Acad.Sci.USA, 90, 1993
1ACJ	QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE 分子名称: ACETYLCHOLINESTERASE, TACRINE 著者 Sussman, J.L, Harel, M, Silman, I. 登録日 1993-08-18 公開日 1994-08-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc.Natl.Acad.Sci.USA, 90, 1993
2C5G	Torpedo californica acetylcholinesterase in complex with 20mM thiocholine 分子名称: 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Colletier, J.P, Fournier, D, Greenblatt, H.M, Sussman, J.L, Zaccai, G, Silman, I, Weik, M. 登録日 2005-10-27 公開日 2006-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase. Embo J., 25, 2006
2C5F	Torpedo californica acetylcholinesterase in complex with a non hydrolysable substrate analogue, 4-oxo-N,N,N-trimethylpentanaminium 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, ACETYLCHOLINESTERASE, ... 著者 Colletier, J.P, Fournier, D, Greenblatt, H.M, Sussman, J.L, Zaccai, G, Silman, I, Weik, M. 登録日 2005-10-27 公開日 2006-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase. Embo J., 25, 2006
2C4H	Torpedo californica acetylcholinesterase in complex with 500mM acetylthiocholine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ACETYL GROUP, ... 著者 Colletier, J.P, Fournier, D, Greenblatt, H.M, Sussman, J.L, Zaccai, G, Silman, I, Weik, M. 登録日 2005-10-19 公開日 2006-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J., 25, 2006
2C58	Torpedo californica acetylcholinesterase in complex with 20mM acetylthiocholine 分子名称: 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Colletier, J.P, Fournier, D, Greenblatt, H.M, Sussman, J.L, Zaccai, G, Silman, I, Weik, M. 登録日 2005-10-26 公開日 2006-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase. Embo J., 25, 2006

 

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