5NAP
Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17
Summary for 5NAP
Entry DOI | 10.2210/pdb5nap/pdb |
Descriptor | Acetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | acetylcholinesterase, inhibitors, alzheimer's disease, donepezil analogues, green chemistry, hydrolase |
Biological source | Tetronarce californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 63567.28 |
Authors | Caliandro, R.,Pesaresi, A.,Lamba, D. (deposition date: 2017-02-28, release date: 2018-05-02, Last modification date: 2024-01-17) |
Primary citation | Caliandro, R.,Pesaresi, A.,Cariati, L.,Procopio, A.,Oliverio, M.,Lamba, D. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. J Enzyme Inhib Med Chem, 33:794-803, 2018 Cited by PubMed: 29651884DOI: 10.1080/14756366.2018.1458030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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