PDB: 10 resultsInfo pagesStatus searchChemie searchBIRD

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4FM9	Human topoisomerase II alpha bound to DNA Descriptor: DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), DNA topoisomerase 2-alpha, ... Authors: Wendorff, T.J, Schmidt, B.H, Heslop, P, Austin, C.A, Berger, J.M. Deposit date: 2012-06-15 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.901 Å) Cite: The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage. J.Mol.Biol., 424, 2012
5NNE	Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY Authors: Filippakopoulos, P, Picaud, S, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. Deposit date: 2017-04-08 Release date: 2018-05-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73, 2019
5GWK	Human topoisomerase IIalpha in complex with DNA and etoposide Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... Authors: Wang, Y.R, Wu, C.C, Chan, N.L. Deposit date: 2016-09-12 Release date: 2017-08-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.152 Å) Cite: Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
4R1F	Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4 Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-alpha, GLYCEROL, ... Authors: Stanger, F.V, Schirmer, T. Deposit date: 2014-08-05 Release date: 2014-09-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Structure of the N-Terminal Gyrase B Fragment in Complex with ADPPi Reveals Rigid-Body Motion Induced by ATP Hydrolysis Plos One, 9, 2014
6ZY7	Cryo-EM structure of the entire Human topoisomerase II alpha in State 1 Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... Authors: Vanden Broeck, A, Lamour, V. Deposit date: 2020-07-30 Release date: 2021-05-26 Last modified: 2021-06-02 Method: ELECTRON MICROSCOPY (4.64 Å) Cite: Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
6ZY6	Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... Authors: Vanden Broeck, A, Lamour, V. Deposit date: 2020-07-30 Release date: 2021-05-26 Last modified: 2021-06-02 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
6ZY8	Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... Authors: Vanden Broeck, A, Lamour, V. Deposit date: 2020-07-30 Release date: 2021-05-26 Last modified: 2021-06-02 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
6ZY5	Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1 Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... Authors: Vanden Broeck, A, Lamour, V. Deposit date: 2020-07-30 Release date: 2021-05-26 Last modified: 2021-06-02 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
1ZXM	Human Topo IIa ATPase/AMP-PNP Descriptor: DNA topoisomerase II, alpha isozyme, MAGNESIUM ION, ... Authors: Wei, H, Ruthenburg, A.J, Bechis, S.K, Verdine, G.L. Deposit date: 2005-06-08 Release date: 2005-08-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase. J.Biol.Chem., 280, 2005
1ZXN	Human DNA topoisomerase IIa ATPase/ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase II, alpha isozyme, ... Authors: Wei, H, Ruthenburg, A.J, Bechis, S.K, Verdine, G.L. Deposit date: 2005-06-08 Release date: 2005-08-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase. J.Biol.Chem., 280, 2005