Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac)

Summary for 5NNE

DescriptorBromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, transcription, complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight16487.02
Filippakopoulos, P.,Picaud, S.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (deposition date: 2017-04-08, release date: 2018-05-16, Last modification date: 2019-02-20)
Primary citation
Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73:621-638.e17, 2019
PubMed: 30554943 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2018.11.006
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.165400 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution