5NNE

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac)

Summary for 5NNE

DescriptorBromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, transcription, complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight16487.02
Authors
Filippakopoulos, P.,Picaud, S.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (deposition date: 2017-04-08, release date: 2018-05-16, Last modification date: 2019-02-20)
Primary citation
Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73:621-638.e17, 2019
PubMed: 30554943 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2018.11.006
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.165400 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution