6ZY5

Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1

Summary for 6ZY5

• Entry DOI: 10.2210/pdb6zy5/pdb
• EMDB information: 11550
• Descriptor: DNA topoisomerase 2-alpha, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... (4 entities in total)
• Functional Keywords: human topoisomerase, etoposide, dna, isomerase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 368845.86

Authors

Vanden Broeck, A.,Lamour, V. (deposition date: 2020-07-30, release date: 2021-05-26, Last modification date: 2021-06-02)

• Primary citation: Vanden Broeck, A.,Lotz, C.,Drillien, R.,Haas, L.,Bedez, C.,Lamour, V.; Structural basis for allosteric regulation of Human Topoisomerase II alpha.; Nat Commun, 12:2962-2962, 2021; PubMed: 34016969; DOI: 10.1038/s41467-021-23136-6

Experimental method

ELECTRON MICROSCOPY (3.6 Å)