6ZY5

Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (B, A)	DNA topoisomerase 2-alpha	polymer	1531	174654.4	2	UniProt (P11388) Pfam (PF02518) Pfam (PF00204) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) Pfam (PF08070)	Homo sapiens (Human)	DNA topoisomerase II,alpha isozyme
2	B, D (D, F)	DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3')	polymer	17	5099.3	2		Homo sapiens
3	C, E (E, C)	DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3')	polymer	13	4080.7	2		Homo sapiens
4	G, H (D, F)	(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside	non-polymer		588.6	2	Chemie (EVP) PubChem (16394664) PubChem (16401497) PubChem (17571827) PubChem (3310) PubChem (24214025) PubChem (44291969) PubChem (16757762) PubChem (44343101) PubChem (44439411) PubChem (45356822) PubChem (23947062) PubChem (40469452) PubChem (57835439) PubChem (44399307) PubChem (439525) PubChem (58934286) PubChem (59516320) PubChem (59890041) PubChem (59935043) PubChem (59969579) PubChem (59981749) PubChem (59981750) PubChem (60046278) PubChem (68028947) PubChem (70840214) PubChem (70973405) PubChem (50989217) PubChem (50936917) PubChem (71774979) PubChem (54395107) PubChem (56841827) PubChem (73707413) PubChem (59360017) PubChem (59910346) PubChem (59991120) PubChem (68297502) PubChem (143627016) PubChem (143179527) PubChem (36462) PubChem (90657341) PubChem (90721503) PubChem (90928389) PubChem (284997) PubChem (73896870) PubChem (487698) PubChem (89809018) PubChem (91528489) PubChem (92209273) PubChem (71109688) PubChem (92211248) PubChem (92481363) PubChem (5284558) PubChem (98044669) PubChem (98456097) PubChem (99940883) PubChem (100810256) PubChem (6419930) PubChem (92209272) PubChem (92209274) PubChem (92209275) PubChem (92215927) PubChem (6604389) PubChem (122535989) PubChem (6708815) PubChem (124747955) PubChem (92481364) PubChem (9851398) PubChem (129010358) PubChem (129427216) PubChem (129426541) PubChem (129539581) PubChem (129427217) PubChem (129539582) PubChem (96545492) PubChem (6604625) PubChem (6610299) PubChem (98044670) PubChem (98047570) PubChem (98047571) PubChem (98047572) PubChem (98456096) PubChem (98456098) PubChem (99940884) PubChem (101060364) PubChem (101616479) PubChem (101872048) PubChem (134694737) PubChem (117627571) PubChem (117987058) PubChem (71163169) PubChem (11870443) PubChem (11870444) PubChem (9851399) PubChem (9916469) PubChem (10077076) PubChem (137370657) PubChem (13269642) PubChem (11072012) PubChem (11758093) PubChem (142236013) PubChem (11870245) PubChem (11870445) PubChem (124747952) PubChem (124747953) PubChem (124747954) PubChem (124762382) PubChem (13269634) PubChem (13269638) PubChem (146156165) PubChem (155239770) PubChem (171042228) PubChem (172012121) PubChem (129406641) PubChem (129416190) PubChem (129426542) PubChem (129426543) PubChem (129539580) PubChem (129539583) PubChem (135056244) PubChem (137704929) PubChem (144658263) PubChem (145365700) PubChem (153427708) PubChem (154700020) PubChem (156133909) PubChem (163016457) PubChem (163016458) PubChem (163016459) PubChem (163016460) PubChem (163016461) PubChem (164643737) PubChem (164935527) PubChem (167092395) PubChem (168251311) PubChem (169440327) PubChem (172372122)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	367668.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1177.1
All*	Total formula weight	368845.9

*Water molecules are not included.