4FM9
Human topoisomerase II alpha bound to DNA
Summary for 4FM9
Entry DOI | 10.2210/pdb4fm9/pdb |
Descriptor | DNA topoisomerase 2-alpha, DNA (5'-D(P*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), ... (6 entities in total) |
Functional Keywords | topoisomerase, dna-binding, protein-dna complex, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P11388 |
Total number of polymer chains | 3 |
Total formula weight | 97478.31 |
Authors | Wendorff, T.J.,Schmidt, B.H.,Heslop, P.,Austin, C.A.,Berger, J.M. (deposition date: 2012-06-15, release date: 2012-08-08, Last modification date: 2024-02-28) |
Primary citation | Wendorff, T.J.,Schmidt, B.H.,Heslop, P.,Austin, C.A.,Berger, J.M. The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage. J.Mol.Biol., 424:109-124, 2012 Cited by PubMed: 22841979DOI: 10.1016/j.jmb.2012.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.901 Å) |
Structure validation
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