4FM9

Human topoisomerase II alpha bound to DNA

Summary for 4FM9

• Entry DOI: 10.2210/pdb4fm9/pdb
• Descriptor: DNA topoisomerase 2-alpha, DNA (5'-D(P*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), ... (6 entities in total)
• Functional Keywords: topoisomerase, dna-binding, protein-dna complex, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P11388
• Total number of polymer chains: 3
• Total formula weight: 97478.31

Authors

Wendorff, T.J.,Schmidt, B.H.,Heslop, P.,Austin, C.A.,Berger, J.M. (deposition date: 2012-06-15, release date: 2012-08-08, Last modification date: 2024-02-28)

• Primary citation: Wendorff, T.J.,Schmidt, B.H.,Heslop, P.,Austin, C.A.,Berger, J.M.; The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.; J.Mol.Biol., 424:109-124, 2012; PubMed: 22841979; DOI: 10.1016/j.jmb.2012.07.014

Experimental method

X-RAY DIFFRACTION (2.901 Å)