6ZY7
Cryo-EM structure of the entire Human topoisomerase II alpha in State 1
Summary for 6ZY7
Entry DOI | 10.2210/pdb6zy7/pdb |
EMDB information | 11553 |
Descriptor | DNA topoisomerase 2-alpha, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... (5 entities in total) |
Functional Keywords | human topoisomerase, etoposide, dna, isomerase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 369858.26 |
Authors | Vanden Broeck, A.,Lamour, V. (deposition date: 2020-07-30, release date: 2021-05-26, Last modification date: 2021-06-02) |
Primary citation | Vanden Broeck, A.,Lotz, C.,Drillien, R.,Haas, L.,Bedez, C.,Lamour, V. Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12:2962-2962, 2021 Cited by PubMed: 34016969DOI: 10.1038/s41467-021-23136-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.64 Å) |
Structure validation
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