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3N6L
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The crystal structure of RNA-dependent RNA polymerase of EV71 virus
分子名称: NICKEL (II) ION, RNA-dependent RNA polymerase
著者Wu, Y, Rao, Z.H.
登録日2010-05-26
公開日2011-06-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
4HHJ
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BU of 4hhj by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase
分子名称: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ...
著者Noble, C.G, Lescar, J.
登録日2012-10-10
公開日2013-02-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
6KWR
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BU of 6kwr by Molmil
Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form)
分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (31-MER), ...
著者Shi, W, Gong, P.
登録日2019-09-08
公開日2019-12-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
Nucleic Acids Res., 48, 2020
6KWQ
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BU of 6kwq by Molmil
Crystal structure of enterovirus 71 polymerase elongation complex (native form)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ...
著者Shi, W, Gong, P.
登録日2019-09-08
公開日2019-12-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
Nucleic Acids Res., 48, 2020
5U04
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BU of 5u04 by Molmil
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
分子名称: PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp
著者Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G.
登録日2016-11-22
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase.
Nat Commun, 8, 2017
6IZZ
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BU of 6izz by Molmil
The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678
分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, Genome polyprotein, ZINC ION
著者Shimizu, H, Sekine, S.
登録日2018-12-20
公開日2019-12-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019
6J00
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BU of 6j00 by Molmil
The RNA-dependent RNA polymerase domain of dengue 3 NS5
分子名称: Genome polyprotein, ZINC ION
著者Shimizu, H, Sekine, S.
登録日2018-12-20
公開日2019-12-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019
6IZY
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BU of 6izy by Molmil
The RNA-dependent RNA polymerase domain of dengue 2 NS5
分子名称: COBALT (II) ION, Genome polyprotein, ZINC ION
著者Shimizu, H, Sekine, S.
登録日2018-12-20
公開日2019-12-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019
6IZX
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BU of 6izx by Molmil
The RNA-dependent RNA polymerase domain of dengue 2 NS5, bound with RK-0404678
分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, COBALT (II) ION, Genome polyprotein, ...
著者Shimizu, H, Sekine, S.
登録日2018-12-20
公開日2019-12-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019
1U09
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BU of 1u09 by Molmil
Footand Mouth Disease Virus RNA-dependent RNA polymerase
分子名称: polyprotein
著者Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N.
登録日2004-07-13
公開日2004-08-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA
J.Biol.Chem., 279, 2004
3QID
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BU of 3qid by Molmil
Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase
分子名称: GLYCEROL, MANGANESE (III) ION, RNA dependent RNA polymerase, ...
著者Kim, K.H, Intekhab, A, Lee, J.H.
登録日2011-01-27
公開日2011-12-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase.
J.Gen.Virol., 92, 2011
8WIL
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BU of 8wil by Molmil
Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ...
著者Wang, X, Jing, X, Deng, F, Gong, P.
登録日2023-09-24
公開日2024-01-17
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase.
Nucleic Acids Res., 52, 2024
8WIM
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BU of 8wim by Molmil
Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ...
著者Wang, X, Jing, X, Deng, F, Gong, P.
登録日2023-09-24
公開日2024-01-17
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase.
Nucleic Acids Res., 52, 2024
3JA4
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BU of 3ja4 by Molmil
RNA-dependent RNA polymerases of transcribing cypoviruses
分子名称: RNA-dependent RNA polymerase
著者Liu, H, Cheng, L.
登録日2015-04-20
公開日2015-10-28
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.
Science, 349, 2015
4HDH
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BU of 4hdh by Molmil
Crystal Structure of viral RdRp in complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
著者Surana, P, Nair, D.T.
登録日2012-10-02
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4HDG
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BU of 4hdg by Molmil
Crystal Structure of viral RdRp in complex with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
著者Surana, P, Nair, D.T.
登録日2012-10-02
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4MTP
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BU of 4mtp by Molmil
RdRp from Japanesese Encephalitis Virus
分子名称: RNA dependent RNA polymerase, ZINC ION
著者Surana, P, Nair, D.T.
登録日2013-09-20
公開日2013-12-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
2PGG
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BU of 2pgg by Molmil
Crystal Structure of a Birnavirus (IBDV) RNA-dependent RNA Polymerase VP1
分子名称: RNA-directed RNA polymerase
著者Pan, J, Vakharia, V.N, Tao, Y.J.
登録日2007-04-09
公開日2007-05-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structure of a birnavirus polymerase reveals a distinct active site topology.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1YUY
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BU of 1yuy by Molmil
HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a
分子名称: RNA-Dependent RNA polymerase, SULFATE ION
著者Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
登録日2005-02-14
公開日2005-03-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
6TZ0
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BU of 6tz0 by Molmil
In situ structure of BmCPV RNA-dependent RNA polymerase at abortive state
分子名称: RNA-dependent RNA Polymerase, Viral structural protein 4
著者Cui, Y.X, Zhang, Y.N, Sun, J.C, Zhou, Z.H.
登録日2019-08-09
公開日2019-11-20
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Conservative transcription in three steps visualized in a double-stranded RNA virus.
Nat.Struct.Mol.Biol., 26, 2019
1HHS
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BU of 1hhs by Molmil
RNA dependent RNA polymerase from dsRNA bacteriophage phi6
分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I.
登録日2000-12-28
公開日2001-03-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Mechanism for Initiating RNA-Dependent RNA Polymerization
Nature, 410, 2001
7BZF
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BU of 7bzf by Molmil
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
分子名称: Non-structural protein 7, Non-structural protein 8, RNA (31-MER), ...
著者Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z.
登録日2020-04-27
公開日2020-06-03
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182, 2020
7B3B
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BU of 7b3b by Molmil
Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1)
分子名称: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ...
著者Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P.
登録日2020-11-30
公開日2020-12-23
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
7B3C
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Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2)
分子名称: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ...
著者Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P.
登録日2020-11-30
公開日2020-12-23
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
2IJD
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Crystal Structure of the Poliovirus Precursor Protein 3CD
分子名称: Picornain 3C, RNA-directed RNA polymerase, SULFATE ION, ...
著者Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M.
登録日2006-09-29
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase.
J.Virol., 81, 2007

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件を2024-05-15に公開中

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