3N6L
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4HHJ
| Dengue serotype 3 RNA-dependent RNA polymerase | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... | 著者 | Noble, C.G, Lescar, J. | 登録日 | 2012-10-10 | 公開日 | 2013-02-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
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6KWR
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6KWQ
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5U04
| Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase | 分子名称: | PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp | 著者 | Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G. | 登録日 | 2016-11-22 | 公開日 | 2017-02-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8, 2017
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6IZZ
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6J00
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6IZY
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6IZX
| The RNA-dependent RNA polymerase domain of dengue 2 NS5, bound with RK-0404678 | 分子名称: | 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, COBALT (II) ION, Genome polyprotein, ... | 著者 | Shimizu, H, Sekine, S. | 登録日 | 2018-12-20 | 公開日 | 2019-12-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
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1U09
| Footand Mouth Disease Virus RNA-dependent RNA polymerase | 分子名称: | polyprotein | 著者 | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | 登録日 | 2004-07-13 | 公開日 | 2004-08-31 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
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3QID
| Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase | 分子名称: | GLYCEROL, MANGANESE (III) ION, RNA dependent RNA polymerase, ... | 著者 | Kim, K.H, Intekhab, A, Lee, J.H. | 登録日 | 2011-01-27 | 公開日 | 2011-12-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase. J.Gen.Virol., 92, 2011
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8WIL
| Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct) | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... | 著者 | Wang, X, Jing, X, Deng, F, Gong, P. | 登録日 | 2023-09-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
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8WIM
| Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct) | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... | 著者 | Wang, X, Jing, X, Deng, F, Gong, P. | 登録日 | 2023-09-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
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3JA4
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4HDH
| Crystal Structure of viral RdRp in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4HDG
| Crystal Structure of viral RdRp in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4MTP
| RdRp from Japanesese Encephalitis Virus | 分子名称: | RNA dependent RNA polymerase, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2013-09-20 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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2PGG
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1YUY
| HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a | 分子名称: | RNA-Dependent RNA polymerase, SULFATE ION | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | 登録日 | 2005-02-14 | 公開日 | 2005-03-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
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6TZ0
| In situ structure of BmCPV RNA-dependent RNA polymerase at abortive state | 分子名称: | RNA-dependent RNA Polymerase, Viral structural protein 4 | 著者 | Cui, Y.X, Zhang, Y.N, Sun, J.C, Zhou, Z.H. | 登録日 | 2019-08-09 | 公開日 | 2019-11-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Conservative transcription in three steps visualized in a double-stranded RNA virus. Nat.Struct.Mol.Biol., 26, 2019
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1HHS
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 | 分子名称: | MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | 登録日 | 2000-12-28 | 公開日 | 2001-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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7BZF
| COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (31-MER), ... | 著者 | Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. | 登録日 | 2020-04-27 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell, 182, 2020
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7B3B
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7B3C
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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2IJD
| Crystal Structure of the Poliovirus Precursor Protein 3CD | 分子名称: | Picornain 3C, RNA-directed RNA polymerase, SULFATE ION, ... | 著者 | Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M. | 登録日 | 2006-09-29 | 公開日 | 2007-02-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J.Virol., 81, 2007
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