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5PZK	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-(4-FLUOROPHENYL)-N-METHYL-6-[(METHYLSULFONYL)AMINO]-5-(PROPAN-2-YLOXY)-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZP	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 4-FLUORO-2-(4-FLUOROPHENYL)-N-METHYL-5-(2-METHYL-5-{[1-(PYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}PHENYL)-1-BENZOFURAN-3-CARBOXAMIDE (BMS-929075) 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
8BE0	Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-10-20 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.34 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
8BDR	Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-10-19 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
8BF5	Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-10-24 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7ZPM	Influenza A/H7N9 polymerase apo-protein dimer complex 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7ZPL	Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook 分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
8BEK	Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-10-21 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
6QCX	Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer 分子名称: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCV	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP 分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCW	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCT	Influenza B polymerase elongation complex 分子名称: 3 end, 5 end, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2018-12-30 公開日 2019-06-05 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
7EU1	The cryo-EM structure of A. thaliana Pol IV-RDR2 holoenzyme 分子名称: DNA-directed RNA polymerase IV subunit 1, DNA-directed RNA polymerases II and IV subunit 5A, DNA-directed RNA polymerases II, ... 著者 Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. 登録日 2021-05-15 公開日 2021-12-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
7EU0	The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex 分子名称: DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... 著者 Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. 登録日 2021-05-15 公開日 2021-12-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
1HHT	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template 分子名称: DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2000-12-28 公開日 2001-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HI1	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus bound NTP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, P2 PROTEIN 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2001-01-01 公開日 2001-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HI8	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 分子名称: MAGNESIUM ION, P2 PROTEIN 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2001-01-03 公開日 2001-03-27 最終更新日 2019-09-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HI0	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus initiation complex 分子名称: DNA (5'-(*TP*TP*TP*CP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2000-12-31 公開日 2001-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
2GIR	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor 分子名称: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
6QCS	Influenza B polymerase pre-initiation complex 分子名称: 3 end, 5 end, Capped RNA, ... 著者 Cusack, S, Kouba, T. 登録日 2018-12-30 公開日 2019-06-05 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
2GIQ	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor 分子名称: 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
7RKP	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 分子名称: (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-07-22 公開日 2022-07-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
2ZTT	Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus 分子名称: Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Sugiyama, K, Obayashi, E, Park, S.-Y. 登録日 2008-10-08 公開日 2009-06-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase Embo J., 28, 2009
4NLV	Poliovirus Polymerase - G289A/C290F Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2014-03-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
4NLT	Poliovirus Polymerase - S291P Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2014-03-26 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014

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