7RKP

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733

Summary for 7RKP

• Entry DOI: 10.2210/pdb7rkp/pdb
• Descriptor: Polymerase acidic protein, Hexa Vinylpyrrolidone K15, (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, ... (6 entities in total)
• Functional Keywords: nuclease, influenza, inhibitor resistance, viral protein-inhibitor complex, hydrolase, viral protein
• Biological source: Influenza A virus (strain swl A/California/04/2009 H1N1); More
• Total number of polymer chains: 1
• Total formula weight: 24624.67

Authors

Cuypers, M.G.,Slavish, J.P.,Rankovic, Z.,White, S.W. (deposition date: 2021-07-22, release date: 2022-07-27, Last modification date: 2023-10-25)

• Primary citation: Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W.; Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.; Eur.J.Med.Chem., 247:115035-115035, 2023; PubMed: 36603507; DOI: 10.1016/j.ejmech.2022.115035

Experimental method

X-RAY DIFFRACTION (2.36 Å)