PDB: 102 resultsInfo pagesStatus searchChemie searchBIRD

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4ZRK	Merlin-FERM and Lats1 complex Descriptor: Merlin, Serine/threonine-protein kinase LATS1 Authors: Lin, Z, Li, Y, Wei, Z, Zhang, M. Deposit date: 2015-05-12 Release date: 2015-06-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.316 Å) Cite: Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res., 25, 2015
6QLZ	IDOL F3ab subdomain Descriptor: E3 ubiquitin-protein ligase MYLIP Authors: Martinelli, L, Johansson, P, Wan, P.T, Gunnarsson, J, Guo, H, Boyd, H. Deposit date: 2019-02-01 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.343 Å) Cite: Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. J.Biol.Chem., 295, 2020
8CIU	The FERM domain of human moesin mutant H288A Descriptor: Moesin Authors: Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.393 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
3X23	Radixin complex Descriptor: Peptide from Matrix metalloproteinase-14, Radixin Authors: Terawaki, S, Kitano, K, Aoyama, M, Mori, T, Hakoshima, T. Deposit date: 2014-12-09 Release date: 2015-10-21 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.396 Å) Cite: MT1-MMP recognition by ERM proteins and its implication in CD44 shedding Genes Cells, 20, 2015
1J19	Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide Descriptor: 16-mer peptide from Intercellular adhesion molecule-2, radixin Authors: Hamada, K, Shimizu, T, Yonemura, S, Tsukita, S, Tsukita, S, Hakoshima, T. Deposit date: 2002-12-02 Release date: 2003-03-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex EMBO J., 22, 2003
6QLY	IDOL FERM domain Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase MYLIP, SULFATE ION Authors: Martinelli, L, Sixma, T.K. Deposit date: 2019-02-01 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. J.Biol.Chem., 295, 2020
2D10	Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide Descriptor: Ezrin-radixin-moesin binding phosphoprotein 50, Radixin Authors: Terawaki, S, Maesaki, R, Hakoshima, T. Deposit date: 2005-08-11 Release date: 2006-07-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for NHERF recognition by ERM proteins Structure, 14, 2006
7EDR	The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin Descriptor: Moesin/ezrin/radixin homolog 2 Authors: Zhang, F, Long, J, Zhou, H. Deposit date: 2021-03-16 Release date: 2021-04-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.527 Å) Cite: The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin. Biochem.Biophys.Res.Commun., 553, 2021
8CIT	The FERM domain of human moesin mutant L281R Descriptor: Moesin Authors: Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-02-10 Release date: 2023-03-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.536 Å) Cite: Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
4P7I	Crystal structure of the Merlin FERM/DCAF1 complex Descriptor: GLYCEROL, Merlin, Protein VPRBP Authors: Wei, Z, Li, Y, Zhang, M. Deposit date: 2014-03-27 Release date: 2014-04-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1. J.Biol.Chem., 289, 2014
6CDS	Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ... Authors: Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T. Deposit date: 2018-02-09 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2. Nat Commun, 9, 2018
3U8Z	human merlin FERM domain Descriptor: Merlin Authors: Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T. Deposit date: 2011-10-17 Release date: 2011-11-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. Protein Sci., 20, 2011
1E5W	Structure of isolated FERM domain and first long helix of moesin Descriptor: MOESIN Authors: Edwards, S.D, Keep, N.H. Deposit date: 2000-08-03 Release date: 2001-06-27 Last modified: 2015-02-11 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The 2.7 A Crystal Structure of the Activated Ferm Domain of Moesin: An Analysis of Structural Changes on Activation Biochemistry, 40, 2001
4ZRI	Crystal structure of Merlin-FERM and Lats2 Descriptor: Merlin, Serine/threonine-protein kinase LATS2 Authors: Li, F, Zhou, H, Long, J, Shen, Y. Deposit date: 2015-05-12 Release date: 2015-06-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res., 25, 2015
1GG3	CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN Descriptor: ERYTHROID MEMBRANE PROTEIN 4.1R Authors: Han, B.G. Deposit date: 2000-07-11 Release date: 2001-01-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization. Nat.Struct.Biol., 7, 2000
1GC7	CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN Descriptor: RADIXIN Authors: Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. Deposit date: 2000-07-21 Release date: 2000-09-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J., 19, 2000
2D2Q	Crystal structure of the dimerized radixin FERM domain Descriptor: Radixin Authors: Kitano, K, Yusa, F, Hakoshima, T. Deposit date: 2005-09-15 Release date: 2006-04-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304 ACTA CRYSTALLOGR.,SECT.F, 62, 2006
2EMT	Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1 Descriptor: P-selectin glycoprotein ligand 1, Radixin Authors: Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T. Deposit date: 2007-03-28 Release date: 2008-03-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of PSGL-1 binding to ERM proteins Genes Cells, 12, 2007
2D11	Crystal structure of the Radixin FERM domain complexed with the NHERF-2 C-terminal tail peptide Descriptor: Na(+)/H(+) exchange regulatory cofactor NHE-RF2, Radixin Authors: Terawaki, S, Maesaki, R, Hakoshima, T. Deposit date: 2005-08-11 Release date: 2006-07-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structural basis for NHERF recognition by ERM proteins Structure, 14, 2006
1ISN	Crystal structure of merlin FERM domain Descriptor: merlin Authors: Shimizu, T, Seto, A, Maita, N, Hamada, K, Tsukita, S, Tsukita, S, Hakoshima, T. Deposit date: 2001-12-13 Release date: 2002-04-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J.Biol.Chem., 277, 2002
1GC6	CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, RADIXIN Authors: Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. Deposit date: 2000-07-21 Release date: 2000-09-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J., 19, 2000
2EMS	Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule CD43 Descriptor: Leukosialin, Radixin Authors: Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T. Deposit date: 2007-03-28 Release date: 2008-04-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins J.Mol.Biol., 381, 2008
6D2Q	Crystal structure of the FERM domain of zebrafish FARP1 Descriptor: FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) Authors: Kuo, Y.C, Zhang, X. Deposit date: 2018-04-13 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structural analyses of FERM domain-mediated membrane localization of FARP1. Sci Rep, 8, 2018
8GXE	PTPN21 FERM PTP complex Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 Authors: Chen, L, Zheng, Y.Y, Zhou, C. Deposit date: 2022-09-19 Release date: 2023-09-27 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
2I1K	Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution Descriptor: CHLORIDE ION, GLYCEROL, Moesin, ... Authors: Nance, M.R, Tesmer, J.J.G. Deposit date: 2006-08-14 Release date: 2006-12-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3 Å) Cite: Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain. J.Mol.Biol., 365, 2007

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