4ZRI

Crystal structure of Merlin-FERM and Lats2

Summary for 4ZRI

• Entry DOI: 10.2210/pdb4zri/pdb
• Related: 4ZRJ 4ZRK
• Descriptor: Merlin, Serine/threonine-protein kinase LATS2 (3 entities in total)
• Functional Keywords: merlin, ferm, lats2, signaling protein-transferase complex, signaling protein/transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 7: Cytoplasm, perinuclear region. Isoform 9: Cytoplasm, perinuclear region. Isoform 10: Nucleus: P35240; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q9NRM7
• Total number of polymer chains: 4
• Total formula weight: 83089.76

Authors

Li, F.,Zhou, H.,Long, J.,Shen, Y. (deposition date: 2015-05-12, release date: 2015-06-17, Last modification date: 2023-11-08)

• Primary citation: Li, Y.,Zhou, H.,Li, F.,Chan, S.W.,Lin, Z.,Wei, Z.,Yang, Z.,Guo, F.,Lim, C.J.,Xing, W.,Shen, Y.,Hong, W.,Long, J.,Zhang, M.; Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway; Cell Res., 25:801-817, 2015; PubMed: 26045165; DOI: 10.1038/cr.2015.69

Experimental method

X-RAY DIFFRACTION (2.7 Å)