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1J7N
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Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
分子名称: Lethal Factor, mitogen-activated protein kinase kinase 2
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-07-13
公開日2001-11-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1PWP
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Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
分子名称: Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
分子名称: Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.52 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
分子名称: LF20, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
分子名称: LF20, Lethal factor
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
分子名称: 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1XFX
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2017-12-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1Y0V
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
分子名称: CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.-J.
登録日2004-11-16
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
1XFU
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Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFW
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFV
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
著者Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1YQY
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Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
分子名称: (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION
著者Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A.
登録日2005-02-02
公開日2005-05-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZXV
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X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
分子名称: (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID, ZINC ION, lethal factor
著者Wong, T.Y, Liddington, R.C.
登録日2005-06-08
公開日2005-07-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Efficient synthetic inhibitors of anthrax lethal factor.
Proc.Natl.Acad.Sci.Usa, 102, 2005
3KWV
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Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
分子名称: CALCIUM ION, Lethal factor, Protective antigen PA-63
著者Feld, G.K, Kintzer, A.F, Krantz, B.A.
登録日2009-12-01
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers.
Nat.Struct.Mol.Biol., 17, 2010
2L0R
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Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center
分子名称: Lethal factor
著者Dalkas, G.A, Chasapis, C.T, Gkazonis, P.V, Bentrop, D.A, Spyroulias, G.A.
登録日2010-07-15
公開日2010-12-22
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Conformational dynamics of the anthrax lethal factor catalytic center.
Biochemistry, 49, 2010
4DV8
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Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
分子名称: (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, Lethal factor, MALONATE ION, ...
著者Margosiak, S.A, Sankaran, B.
登録日2012-02-22
公開日2012-03-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.632 Å)
主引用文献Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg.Med.Chem.Lett., 22, 2012
4FXQ
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Full-length Certhrax toxin from Bacillus cereus in complex with Inhibitor P6
分子名称: 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, Putative ADP-ribosyltransferase Certhrax, ...
著者Visschedyk, D.D, Dimov, S, Kimber, M.S, Park, H.W, Merrill, A.R.
登録日2012-07-03
公開日2012-09-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9599 Å)
主引用文献Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4GF1
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Crystal Structure of Certhrax
分子名称: Putative ADP-ribosyltransferase Certhrax, UNKNOWN ATOM OR ION
著者Hong, B.S, Dimov, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC)
登録日2012-08-02
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4PKT
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Anthrax toxin lethal factor with bound small molecule inhibitor 13
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKS
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Anthrax toxin lethal factor with bound small molecule inhibitor 11
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKW
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Anthrax toxin lethal factor with bound small molecule inhibitor GM6001
分子名称: 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKQ
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Anthrax toxin lethal factor with bound zinc
分子名称: 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ...
著者Maize, K.M, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014

 

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