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8OQ3
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BU of 8oq3 by Molmil
Structure of methylamine treated human complement C3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gadeberg, T.A.F, Andersen, G.R.
登録日2023-04-11
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of methylamine treated human complement C3
To Be Published
8OVB
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BU of 8ovb by Molmil
Human Complement C3b in complex with Trypanosoma brucei ISG65.
分子名称: Complement C3, Complement C3f fragment, ISG65 G
著者Cook, A.D, Higgins, M.K.
登録日2023-04-25
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of complement factor C3b inhibition by the trypanosome ISG65 receptor.
To be published
8COE
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BU of 8coe by Molmil
complement C5 in complex with the LCP0195 nanobody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ...
著者Andersen, G.R, Pedersen, D.V.
登録日2023-02-28
公開日2024-01-03
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.
Mol.Immunol., 165, 2023
8CML
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BU of 8cml by Molmil
Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ...
著者De la O Becerra, K.I, Gros, P.
登録日2023-02-20
公開日2023-09-27
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies.
J.Biol.Chem., 299, 2023
8EOK
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BU of 8eok by Molmil
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
著者Andersen, J.F, Lei, H.
登録日2022-10-03
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8ENU
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BU of 8enu by Molmil
Structure of the C3bB proconvertase in complex with lufaxin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
著者Andersen, J.F, Lei, H.
登録日2022-09-30
公開日2023-08-09
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8CEM
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BU of 8cem by Molmil
Structure of bovine native C3, re-refinement
分子名称: Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Andersen, G.R, Fredslund, F.
登録日2023-02-02
公開日2023-04-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
7ZGJ
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BU of 7zgj by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7ZGK
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BU of 7zgk by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
8B0H
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BU of 8b0h by Molmil
2C9, C5b9-CD59 cryoEM structure
分子名称: CD59 glycoprotein, Complement C5, Complement component C6, ...
著者Couves, E.C, Gardner, S, Bubeck, D.
登録日2022-09-07
公開日2023-02-22
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0G
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BU of 8b0g by Molmil
2C9, C5b9-CD59 structure
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ...
著者Couves, E.C, Gardner, S, Bubeck, D.
登録日2022-09-07
公開日2023-02-22
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0F
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BU of 8b0f by Molmil
CryoEM structure of C5b8-CD59
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Bubeck, D, Couves, E.C, Gardner, S.
登録日2022-09-07
公開日2023-02-22
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8AYH
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BU of 8ayh by Molmil
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
分子名称: 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid, Cobra venom factor, Complement C5 alpha chain, ...
著者Srinivas, H.
登録日2022-09-02
公開日2022-12-21
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献A small-molecule inhibitor of C5 complement protein.
Nat.Chem.Biol., 15, 2019
7VON
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BU of 7von by Molmil
Native alpha-2-macroglobulin monomer
分子名称: Alpha-2-macroglobulin
著者Huang, X, Wang, Y.
登録日2021-10-14
公開日2022-11-16
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7VOO
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BU of 7voo by Molmil
Induced alpha-2-macroglobulin monomer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Huang, X, Wang, Y, Ping, Z.
登録日2021-10-14
公開日2022-10-19
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7NOZ
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BU of 7noz by Molmil
Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ...
著者Lorenzen, J, Pedersen, D.V, Andersen, G.R.
登録日2021-02-26
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging.
Protein Sci., 31, 2022
7PI6
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BU of 7pi6 by Molmil
Trypanosoma brucei ISG65 bound to human complement C3d
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 65 kDa invariant surface glycoprotein, Complement C3dg fragment, ...
著者Cook, A.D, Higgins, M.K.
登録日2021-08-19
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Nat Commun, 13, 2022
7UE9
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BU of 7ue9 by Molmil
Structure of anti-C3d Fab(3d8b) in complex with C3d
分子名称: Complement C3dg fragment, Fab heavy chain, Fab light chain, ...
著者Olland, A.M, White, A, Suto, R.K.
登録日2022-03-21
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue.
Front Immunol, 13, 2022
7Q62
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BU of 7q62 by Molmil
Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
著者Nielsen, N.S, Zarantonello, A, Andersen, G.R.
登録日2021-11-05
公開日2022-04-20
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q1Y
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BU of 7q1y by Molmil
X-ray structure of human A2ML1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ...
著者Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S.
登録日2021-10-22
公開日2022-04-20
最終更新日2022-11-02
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q60
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BU of 7q60 by Molmil
Structure of TEV cleaved A2ML1 (A2ML1-TE)
分子名称: Alpha-2-macroglobulin-like protein 1
著者Nielsen, N.S, Zarantonello, A, Andersen, G.R.
登録日2021-11-05
公開日2022-04-20
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q5Z
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BU of 7q5z by Molmil
Cryo-EM structure of native human A2ML1
分子名称: Alpha-2-macroglobulin-like protein 1
著者Zarantonello, A, Nielsen, N.S, Andersen, G.R.
登録日2021-11-05
公開日2022-04-20
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q61
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BU of 7q61 by Molmil
Structure of TEV conjugated A2ML1 (A2ML1-TC)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
著者Nielsen, N.S, Zarantonello, A, Andersen, G.R.
登録日2021-11-05
公開日2022-04-20
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7O7L
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BU of 7o7l by Molmil
(h-alpha2M)4 native I
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-20
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7AKK
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BU of 7akk by Molmil
Structure of a complement factor-receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
著者Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C.
登録日2020-10-01
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.395 Å)
主引用文献The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
Nat Commun, 13, 2022

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