PDB: 174 件ウェブページステータス検索Chemie searchBIRD

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5U47	1.95 Angstrom Resolution Crystal Structure of Penicillin Binding Protein 2X from Streptococcus thermophilus 分子名称: ACETATE ION, CHLORIDE ION, Penicillin binding protein 2X 著者 Minasov, G, Shuvalova, L, Cardona-Correa, A, Dubrovska, I, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-12-03 公開日 2016-12-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 1.95 Angstrom Resolution Crystal Structure of Penicillin Binding Protein 2X from Streptococcus thermophilus. To Be Published
2ZC3	Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 分子名称: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, Penicillin-binding protein 2X, SULFATE ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-11-02 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
4KQO	Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin 分子名称: CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
2Z2L	Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae 分子名称: Penicillin-binding protein 2X, SULFATE ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-05-23 公開日 2007-09-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity Antimicrob.Agents Chemother., 51, 2007
4KQQ	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
5TRO	1.8 Angstrom Resolution Crystal Structure of Dimerization and Transpeptidase domains (residues 39-608) of Penicillin-Binding Protein 1 from Staphylococcus aureus. 分子名称: CHLORIDE ION, Penicillin-binding protein 1 著者 Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-10-26 公開日 2016-11-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 1.8 Angstrom Resolution Crystal Structure of Dimerization and Transpeptidase domains (residues 39-608) of Penicillin-Binding Protein 1 from Staphylococcus aureus. To Be Published
5UY7	Crystal structure of a peptidoglycan glycosyltransferase from Burkholderia ambifaria 分子名称: Peptidoglycan glycosyltransferase, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-02-23 公開日 2017-03-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of a peptidoglycan glycosyltransferase from Burkholderia ambifaria To Be Published
5OJ0	Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae in complex with Cefepime 分子名称: Cefepime, Penicillin-binding protein 2X 著者 Bernardo-Garcia, N, Hermoso, J.A. 登録日 2017-07-20 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13, 2018
4KQR	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
4BL2	Crystal structure of PBP2a clinical mutant E150K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, PENICILLIN BINDING PROTEIN 2 PRIME 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2013-04-30 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
7RCX	Crystal structure of C. difficile penicillin-binding protein 2 in apo form 分子名称: GLYCEROL, Penicillin-binding protein, SULFATE ION, ... 著者 Sacco, M, Chen, Y. 登録日 2021-07-08 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022
7RD0	Crystal structure of C. difficile penicillin-binding protein 3 in apo form 分子名称: GLYCEROL, Penicillin-binding protein, ZINC ION 著者 Sacco, M, Chen, Y. 登録日 2021-07-08 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022
7RCW	Crystal structure of C. difficile penicillin-binding protein 2 in complex with ampicillin 分子名称: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Sacco, M, Chen, Y. 登録日 2021-07-08 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022
7RCZ	Crystal structure of C. difficile SpoVD in complex with ampicillin 分子名称: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Sacco, M, Chen, Y. 登録日 2021-07-08 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022
7RCY	Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Penicillin-binding protein, ZINC ION 著者 Sacco, M, Chen, Y. 登録日 2021-07-08 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13, 2022
6R40	Apo structure of R504C mutant of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) 分子名称: Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2019-03-21 公開日 2020-02-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
4CPK	Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, Penicillin binding protein 2 prime, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2014-02-07 公開日 2014-09-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
4BL3	Crystal structure of PBP2a clinical mutant N146K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, PENICILLIN BINDING PROTEIN 2 PRIME, ... 著者 Otero, L.H, Rojas-Altuve, A, Carrasco-Lopez, C, Hermoso, J.A. 登録日 2013-04-30 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
6R3X	Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with piperacillin 分子名称: Peptidoglycan D,D-transpeptidase FtsI, Piperacillin (Open Form) 著者 Bellini, D, Dowson, C.G. 登録日 2019-03-21 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
6R42	Structure of R504C mutant of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with piperacillin 分子名称: Peptidoglycan D,D-transpeptidase FtsI, Piperacillin (Open Form) 著者 Bellini, D, Dowson, C.G. 登録日 2019-03-21 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
6G9P	Structural basis for the inhibition of E. coli PBP2 分子名称: Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-11 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
6G9F	Structural basis for the inhibition of E. coli PBP2 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-10 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
6G0K	Crystal structure of Enterococcus faecium D63r Penicillin-Binding protein 5 (PBP5fm) 分子名称: Low affinity penicillin-binding protein 5 (PBP5), SULFATE ION 著者 Sauvage, E, El Gachi, M, Herman, R, Kerff, F, Charlier, P. 登録日 2018-03-19 公開日 2019-04-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole. To Be Published
6SYN	Crystal structure of Y. pestis penicillin-binding protein 3 分子名称: (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ACETATE ION, Peptidoglycan D,D-transpeptidase FtsI 著者 Pankov, G, Hunter, W.N, Dawson, A. 登録日 2019-09-30 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 The structure of penicillin-binding protein 3 from Yersinia pestis To Be Published
6G9S	Structural basis for the inhibition of E. coli PBP2 分子名称: (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid, Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-11 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019

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