5OJ0

Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae in complex with Cefepime

Summary for 5OJ0

Entry DOI	10.2210/pdb5oj0/pdb
Descriptor	Penicillin-binding protein 2X, Cefepime (3 entities in total)
Functional Keywords	penicillin, b-lactam, cell-wall, transpeptidase, antibiotic
Biological source	Streptococcus pneumoniae
Cellular location	Cell membrane; Single-pass membrane protein: P59676
Total number of polymer chains	1
Total formula weight	77289.54
Authors	Bernardo-Garcia, N.,Hermoso, J.A. (deposition date: 2017-07-20, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citation	Bernardo-Garcia, N.,Mahasenan, K.V.,Batuecas, M.T.,Lee, M.,Hesek, D.,Petrackova, D.,Doubravova, L.,Branny, P.,Mobashery, S.,Hermoso, J.A. Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13:694-702, 2018 Cited by PubMed: 29357220 DOI: 10.1021/acschembio.7b00817 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation