7RCW

Crystal structure of C. difficile penicillin-binding protein 2 in complex with ampicillin

Summary for 7RCW

• Entry DOI: 10.2210/pdb7rcw/pdb
• Descriptor: Penicillin-binding protein, DI(HYDROXYETHYL)ETHER, ACETATE ION, ... (7 entities in total)
• Functional Keywords: peptidoglycan, pbp, pbp2, cell wall, transpeptidase, b-lactam, gram-positive, spore, sporulation, peptide binding protein
• Biological source: Clostridioides difficile (strain R20291) (Peptoclostridium difficile)
• Total number of polymer chains: 1
• Total formula weight: 104670.55

Authors

Sacco, M.,Chen, Y. (deposition date: 2021-07-08, release date: 2022-03-23, Last modification date: 2023-10-18)

• Primary citation: Sacco, M.D.,Wang, S.,Adapa, S.R.,Zhang, X.,Lewandowski, E.M.,Gongora, M.V.,Keramisanou, D.,Atlas, Z.D.,Townsend, J.A.,Gatdula, J.R.,Morgan, R.T.,Hammond, L.R.,Marty, M.T.,Wang, J.,Eswara, P.J.,Gelis, I.,Jiang, R.H.Y.,Sun, X.,Chen, Y.; A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.; Nat Commun, 13:4370-4370, 2022; PubMed: 35902581; DOI: 10.1038/s41467-022-32086-6

Experimental method

X-RAY DIFFRACTION (3 Å)