1B3U
| CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA | Descriptor: | PROTEIN (PROTEIN PHOSPHATASE PP2A) | Authors: | Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D. | Deposit date: | 1998-12-14 | Release date: | 1999-04-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell(Cambridge,Mass.), 96, 1999
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6MQ5
| Structure of human CLASP1 TOG1 | Descriptor: | CLIP-associating protein 1 | Authors: | Leano, J.B, Slep, K.C. | Deposit date: | 2018-10-09 | Release date: | 2019-07-17 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.146 Å) | Cite: | Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1. Plos One, 14, 2019
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6IUR
| A phosphatase complex STRN3-PP2Aa | Descriptor: | PP2A scaffolding subunit, PROPANE, Striatin-3 | Authors: | Tang, Y, Zhou, Z.C. | Deposit date: | 2018-11-30 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell, 38, 2020
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2QMR
| Karyopherin beta2/transportin | Descriptor: | Transportin-1 | Authors: | Cansizoglu, A.E, Chook, Y.M. | Deposit date: | 2007-07-16 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Conformational heterogeneity of karyopherin beta2 is segmental Structure, 15, 2007
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4OO6
| Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) | Descriptor: | RNA-binding protein 39, Transportin-1 | Authors: | Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) | Deposit date: | 2014-01-30 | Release date: | 2014-02-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) to be published
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5J3V
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3ND2
| Structure of Yeast Importin-beta (Kap95p) | Descriptor: | Importin subunit beta-1 | Authors: | Forwood, J.K, Kobe, B. | Deposit date: | 2010-06-06 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures Structure, 18, 2010
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5OWU
| Kap95:Nup1 complex | Descriptor: | Importin subunit beta-1, Nucleoporin NUP1 | Authors: | Stewart, M. | Deposit date: | 2017-09-04 | Release date: | 2017-10-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p. J. Mol. Biol., 349, 2005
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6EF4
| Crystal structure of mouse PP2A Aalpha P179R mutant | Descriptor: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | Authors: | Wang, Z, Shen, G, Xu, W. | Deposit date: | 2018-08-16 | Release date: | 2019-06-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis. Cancer Res., 79, 2019
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2DB0
| Crystal structure of PH0542 | Descriptor: | 253aa long hypothetical protein | Authors: | Nishino, A, Handa, N, Kishishita, S, Murayama, K, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-14 | Release date: | 2006-06-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of PH0542 To be Published
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6XTE
| Human karyopherin RanBP5 (isoform-1) | Descriptor: | Antipain, CHLORIDE ION, Importin-5, ... | Authors: | Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. | Deposit date: | 2020-01-16 | Release date: | 2020-04-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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6XU2
| Human karyopherin RanBP5 (isoform-3) | Descriptor: | Antipain, Importin-5, NICKEL (II) ION | Authors: | Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T. | Deposit date: | 2020-01-17 | Release date: | 2020-04-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.834 Å) | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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4FQ3
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4FDD
| Crystal structure of KAP beta2-PY-NLS | Descriptor: | RNA-binding protein FUS, Transportin-1 | Authors: | Zhang, Z.C, Chook, Y.M. | Deposit date: | 2012-05-28 | Release date: | 2012-07-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc.Natl.Acad.Sci.USA, 109, 2012
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7CYL
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8R23
| INTS9-INTS11-BRAT1 complex | Descriptor: | BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ... | Authors: | Sabath, K, Qiu, C, Jonas, S. | Deposit date: | 2023-11-02 | Release date: | 2024-07-31 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Assembly mechanism of Integrator's RNA cleavage module. Mol.Cell, 84, 2024
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8R2D
| Integrator cleavage module assembly intermediate | Descriptor: | BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 4, ... | Authors: | Sabath, K, Qiu, C, Jonas, S. | Deposit date: | 2023-11-03 | Release date: | 2024-07-31 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Assembly mechanism of Integrator's RNA cleavage module. Mol.Cell, 84, 2024
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8R22
| INTS9-INTS11-BRAT1-WDR73 complex | Descriptor: | BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ... | Authors: | Sabath, K, Qiu, C, Jonas, S. | Deposit date: | 2023-11-02 | Release date: | 2024-07-31 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Assembly mechanism of Integrator's RNA cleavage module. Mol.Cell, 84, 2024
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7XVK
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7VPW
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4JLQ
| Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2 | Descriptor: | Nuclear polyadenylated RNA-binding protein NAB2, Transportin-1 | Authors: | Sampathkumar, P, Gizzi, A, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) | Deposit date: | 2013-03-12 | Release date: | 2013-04-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. J.Struct.Funct.Genom., 14, 2013
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2H4M
| Karyopherin Beta2/Transportin-M9NLS | Descriptor: | Heterogeneous nuclear ribonucleoprotein A1, Transportin-1 | Authors: | Chook, Y.M, Cansizoglu, A.E. | Deposit date: | 2006-05-24 | Release date: | 2006-10-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell(Cambridge,Mass.), 126, 2006
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5TQC
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5VE8
| Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H3 1-28 | Descriptor: | Histone H3, Kap123 | Authors: | An, S, Yoon, J, Song, J.-J, Cho, U.-S. | Deposit date: | 2017-04-04 | Release date: | 2017-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123. Elife, 6, 2017
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5W0V
| Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H4 1-34 | Descriptor: | Histone H4 1-34, Kap123 | Authors: | An, S, Yoon, J, Song, J.-J, Cho, U.-S. | Deposit date: | 2017-05-31 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.821 Å) | Cite: | Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123. Elife, 6, 2017
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