1CEQ
| CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE. | 分子名称: | PROTEIN (L-LACTATE DEHYDROGENASE) | 著者 | Read, J.A, Wilkinson, K.W, Tranter, R, Sessions, R.B, Brady, R.L. | 登録日 | 1999-03-10 | 公開日 | 1999-03-19 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. J.Biol.Chem., 274, 1999
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1IZ9
| Crystal Structure of Malate Dehydrogenase from Thermus thermophilus HB8 | 分子名称: | MALATE DEHYDROGENASE | 著者 | Hirose, R, Hasegawa, T, Yamano, A, Kuramitsu, S, Hamada, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-10-01 | 公開日 | 2002-10-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Malate Dehydrogenase from Thermus themrophilus HB8 To be published
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1U4S
| Plasmodium falciparum lactate dehydrogenase complexed with 2,6-naphthalenedisulphonic acid | 分子名称: | L-lactate dehydrogenase, NAPHTHALENE-2,6-DISULFONIC ACID | 著者 | Conners, R, Cameron, A, Read, J, Schambach, F, Sessions, R.B, Brady, R.L. | 登録日 | 2004-07-26 | 公開日 | 2005-06-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Mol.Biochem.Parasitol., 142, 2005
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4ND2
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2J5K
| 2.0 A resolution structure of the wild type malate dehydrogenase from Haloarcula marismortui (radiation damage series) | 分子名称: | CHLORIDE ION, MALATE DEHYDROGENASE | 著者 | Fioravanti, E, Vellieux, F.M.D, Amara, P, Madern, D, Weik, M. | 登録日 | 2006-09-18 | 公開日 | 2006-09-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Specific Radiation Damage to Acidic Residues and its Relation to Their Chemical and Structural Environment. J.Synchrotron Radiat., 14, 2007
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4QO8
| Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 104 | 分子名称: | (5S)-2-[(2-chlorophenyl)sulfanyl]-5-(2,6-dichlorophenyl)-3-hydroxycyclohex-2-en-1-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2014-06-19 | 公開日 | 2014-07-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 24, 2014
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5KVV
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1T2C
| Plasmodium falciparum lactate dehydrogenase complexed with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-lactate dehydrogenase | 著者 | Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G. | 登録日 | 2004-04-21 | 公開日 | 2004-05-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279, 2004
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6MVA
| LDHA structure in complex with inhibitor 14 | 分子名称: | (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C.E, Ultsch, M, Wei, B. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase To Be Published
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4AJK
| rat LDHA in complex with N-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide | 分子名称: | GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, MALONATE ION, ... | 著者 | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G, Greenwood, R. | 登録日 | 2012-02-16 | 公開日 | 2012-03-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012
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2A92
| Crystal structure of lactate dehydrogenase from Plasmodium vivax: complex with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase | 著者 | Chaikuad, A, Fairweather, V, Conners, R, Joseph-Horne, T, Turgut-Balik, D, Brady, R.L. | 登録日 | 2005-07-11 | 公開日 | 2006-01-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Biochemistry, 44, 2005
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7RRL
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6Q0D
| CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00384414-01 AT 2.05 A RESOLUTION | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-[3-(cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... | 著者 | Dranow, D.M, Davies, D.R. | 登録日 | 2019-08-01 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
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1CET
| CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE. | 分子名称: | N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, PROTEIN (L-LACTATE DEHYDROGENASE) | 著者 | Read, J.A, Wilkinson, K.W, Tranter, R, Sessions, R.B, Brady, R.L. | 登録日 | 1999-03-10 | 公開日 | 1999-03-19 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. J.Biol.Chem., 274, 1999
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5IXS
| Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one | 分子名称: | (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2016-03-23 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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6BAX
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2AA3
| Crystal structure of Plasmodium vivax lactate dehydrogenase complex with APADH | 分子名称: | ACETYL PYRIDINE ADENINE DINUCLEOTIDE, REDUCED, L-lactate dehydrogenase, ... | 著者 | Chaikuad, A, Fairweather, V, Conners, R, Joseph-Horne, T, Turgut-Balik, D, Brady, R.L. | 登録日 | 2005-07-13 | 公開日 | 2006-01-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of Lactate Dehydrogenase from Plasmodium vivax: Complexes with NADH and APADH. Biochemistry, 44, 2005
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4ND3
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4M49
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7CGD
| Silver-bound E.coli malate dehydrogenase | 分子名称: | Malate dehydrogenase, SILVER ION | 著者 | Wang, H, Wang, M, Sun, H. | 登録日 | 2020-07-01 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci, 11, 2020
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2CVQ
| Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | 登録日 | 2005-06-13 | 公開日 | 2005-08-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H) Biochem.Biophys.Res.Commun., 334, 2005
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3DL2
| Hexagonal structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A | 分子名称: | PHOSPHATE ION, SODIUM ION, Ubiquitin-conjugating enzyme E2 variant 3 | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Bountra, C, Wolkstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-06-26 | 公開日 | 2008-07-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Investigation Into the L-Lactate Dehydrogenase Domain of Human Ubiquitin-Conjugating Enzyme E2-Like Isoform A. To be Published
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1A5Z
| LACTATE DEHYDROGENASE FROM THERMOTOGA MARITIMA (TMLDH) | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, CADMIUM ION, L-LACTATE DEHYDROGENASE, ... | 著者 | Auerbach, G, Ostendorp, R, Prade, L, Korndoerfer, I, Dams, T, Huber, R, Jaenicke, R. | 登録日 | 1998-02-18 | 公開日 | 1999-03-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. Structure, 6, 1998
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1LDM
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4OKN
| Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, KANAMYCIN A, L-lactate dehydrogenase A chain, ... | 著者 | Kolappan, S, Craig, L. | 登録日 | 2014-01-22 | 公開日 | 2014-12-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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