PDB: 193 resultsInfo pagesStatus searchChemie searchBIRD

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5OFW	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide Descriptor: 3-chloranyl-4-fluoranyl-benzamide, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-07-11 Release date: 2017-08-16 Last modified: 2019-07-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
6PLG	Crystal structure of human PHGDH complexed with Compound 15 Descriptor: (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid, D-3-phosphoglycerate dehydrogenase, D-MALATE Authors: Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. Deposit date: 2019-06-30 Release date: 2019-07-24 Last modified: 2019-09-04 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
5NZQ	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. Descriptor: 3-(1,3-oxazol-5-yl)aniline, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-05-14 Release date: 2017-06-14 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
6BII	Crystal Structure of Pyrococcus yayanosii Glyoxylate Hydroxypyruvate Reductase in complex with NADP and malonate (re-refinement of 5AOW) Descriptor: GLYCEROL, Glyoxylate reductase, MALONATE ION, ... Authors: Lassalle, L, Shabalin, I.G, Girard, E, Minor, W. Deposit date: 2017-11-02 Release date: 2018-01-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases. Sci Rep, 6, 2016
6PEX	An aldo keto reductase with 2-keto- L-gulonate reductase activity Descriptor: aldo keto reductase Authors: Yong, J, Crystal, S, Robert, D.H, John, B.B. Deposit date: 2019-06-21 Release date: 2019-09-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.581 Å) Cite: An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C inVitis vinifera. J.Biol.Chem., 294, 2019
6PLF	Crystal structure of human PHGDH complexed with Compound 1 Descriptor: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase Authors: Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. Deposit date: 2019-06-30 Release date: 2019-07-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
6CDF	Human CtBP1 (28-378) Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C-terminal-binding protein 1, CALCIUM ION, ... Authors: Royer, W.E, Bellesis, A.G. Deposit date: 2018-02-08 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Assembly of human C-terminal binding protein (CtBP) into tetramers. J. Biol. Chem., 293, 2018
6CDR	Human CtBP1 (28-378) Descriptor: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C-terminal-binding protein 1, ... Authors: Royer, W.E, Bellesis, A.G. Deposit date: 2018-02-09 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.399 Å) Cite: Assembly of human C-terminal binding protein (CtBP) into tetramers. J. Biol. Chem., 293, 2018
5NZP	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Hydroxybenzisoxazole Descriptor: 1,2-benzoxazol-3-ol, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-05-14 Release date: 2017-06-14 Last modified: 2019-05-08 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
5OFV	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid Descriptor: 5-fluoranyl-2-methyl-benzoic acid, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-07-11 Release date: 2017-08-16 Last modified: 2019-07-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
5OFM	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1H-indole Descriptor: 1-methylindol-5-amine, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-07-11 Release date: 2017-08-16 Last modified: 2018-04-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1H-indole To be published
5NZO	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 1-methyl-3-phenyl-1H-pyrazol-5-amine Descriptor: 2-methyl-5-phenyl-pyrazol-3-amine, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-05-14 Release date: 2017-06-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
6CWA	CRYSTAL STRUCTURE PHGDH IN COMPLEX WITH NADH AND 3-PHOSPHOGLYCERATE AT 1.77 A RESOLUTION Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3-PHOSPHOGLYCERIC ACID, D-3-phosphoglycerate dehydrogenase Authors: Davies, D.R, Edwards, T.E. Deposit date: 2018-03-30 Release date: 2019-08-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis. J.Med.Chem., 62, 2019
2D0I	Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 Descriptor: dehydrogenase Authors: Lokanath, N.K, Terao, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-08-02 Release date: 2006-02-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 To be Published
3GVX	Crystal structure of Glycerate dehydrogenase related protein from Thermoplasma acidophilum Descriptor: Glycerate dehydrogenase related protein, POTASSIUM ION Authors: Syed Ibrahim, B, Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2009-03-31 Release date: 2009-04-28 Last modified: 2021-02-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of Glycerate dehydrogenase related protein from Thermoplasma acidophilum To be Published
4XKJ	a Novel D-lactate Dehydrogenase from Sporolactobacillus sp Descriptor: D-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Bo, Y, Hui, D, Xiang, L. Deposit date: 2015-01-12 Release date: 2015-08-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.148 Å) Cite: a Novel D-lactate Dehydrogenase from Sporolactobacillus sp To Be Published
2DBQ	Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (I41) Descriptor: GLYCEROL, Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-16 Release date: 2006-06-16 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate. Acta Crystallogr.,Sect.D, 63, 2007
2DBZ	Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (P61) Descriptor: Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION Authors: Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-16 Release date: 2006-06-16 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate. Acta Crystallogr.,Sect.D, 63, 2007
2DBR	Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (P1) Descriptor: Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION Authors: Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-16 Release date: 2006-06-16 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate. Acta Crystallogr.,Sect.D, 63, 2007
4XYG	GRANULICELLA M. FORMATE DEHYDROGENASE (FDH) Descriptor: Formate dehydrogenase Authors: Cendron, L, Fogal, S, Beneventi, E, Bergantino, E. Deposit date: 2015-02-02 Release date: 2015-07-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX8. Appl.Microbiol.Biotechnol., 99, 2015
4XYB	GRANULICELLA M. FORMATE DEHYDROGENASE (FDH) IN COMPLEX WITH NADP(+) AND NaN3 Descriptor: 1,2-ETHANEDIOL, AZIDE ION, Formate dehydrogenase, ... Authors: Cendron, L, Fogal, S, Beneventi, E, Bergantino, E. Deposit date: 2015-02-02 Release date: 2015-07-08 Last modified: 2015-11-11 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX8. Appl.Microbiol.Biotechnol., 99, 2015
4XYE	GRANULICELLA M. FORMATE DEHYDROGENASE (FDH) IN COMPLEX WITH NAD(+) Descriptor: Formate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Cendron, L, Fogal, S, Beneventi, E, Bergantino, E. Deposit date: 2015-02-02 Release date: 2015-07-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX8. Appl.Microbiol.Biotechnol., 99, 2015
2DLD	D-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-LACTATE DEHYDROGENASE, OXAMIC ACID Authors: Dunn, C.R, Holbrook, J.J. Deposit date: 1995-10-28 Release date: 1996-03-14 Last modified: 2013-11-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Dehydrogenases Engineering to Correct Substrate Inhibition in a Commercial Dehydrogenase To be Published
3JTM	Structure of recombinant formate dehydrogenase from Arabidopsis thaliana Descriptor: AZIDE ION, Formate dehydrogenase, mitochondrial, ... Authors: Timofeev, V.I, Shabalin, I.G, Serov, A.E, Polyakov, K.M, Popov, V.O, Tishkov, V.I, Kuranova, I.P, Samigina, V.R. Deposit date: 2009-09-13 Release date: 2010-09-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure of recombinant formate dehydrogenase from Arabidopsis thaliana to be published
3K5P	Crystal structure of amino acid-binding ACT: D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain from Brucella melitensis Descriptor: 1,2-ETHANEDIOL, D-3-phosphoglycerate dehydrogenase, GLYCEROL Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2009-10-07 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of amino acid-binding ACT: D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain from Brucella melitensis To be Published

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