5NZO
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 1-methyl-3-phenyl-1H-pyrazol-5-amine
Summary for 5NZO
Entry DOI | 10.2210/pdb5nzo/pdb |
Descriptor | D-3-phosphoglycerate dehydrogenase, 2-methyl-5-phenyl-pyrazol-3-amine (3 entities in total) |
Functional Keywords | dehydrogenase, serine metabolism, fbdd, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 42250.64 |
Authors | Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-05-14, release date: 2017-06-14, Last modification date: 2024-01-17) |
Primary citation | Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9:13139-13153, 2018 Cited by PubMed: 29568346DOI: 10.18632/oncotarget.11487 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.29 Å) |
Structure validation
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