5NZP

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Hydroxybenzisoxazole

Summary for 5NZP

Entry DOI	10.2210/pdb5nzp/pdb
Descriptor	D-3-phosphoglycerate dehydrogenase, 1,2-benzoxazol-3-ol (3 entities in total)
Functional Keywords	dehydrogenase, serine metabolism, fbdd, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	44124.64
Authors	Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-05-14, release date: 2017-06-14, Last modification date: 2019-05-08)
Primary citation	Unterlass, J.E.,Basle, A.,Blackburn, T.J.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9:13139-13153, 2018 Cited by PubMed: 29568346 DOI: 10.18632/oncotarget.11487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation