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1F91
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BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I IN COMPLEX WITH C10 FATTY ACID SUBSTRATE
分子名称: BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, DECANOIC ACID, HYDROXIDE ION
著者Olsen, J.G, Kadziola, A, Wettstein-Knowles, P.V, Siggaard-Andersen, M, Larsen, S.
登録日2000-07-06
公開日2001-04-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
6P9M
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Crystal structure of Mycobacterium tuberculosis KasA in complex with O6J
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Capodagli, G.C, Neiditch, M.B.
登録日2019-06-10
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.256 Å)
主引用文献A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Cell Chem Biol, 27, 2020
4QYR
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Streptomyces platensis isomigrastatin ketosynthase domain MgsE KS3
分子名称: ACETIC ACID, AT-less polyketide synthase, CHLORIDE ION, ...
著者Kim, Y, Li, H, Endres, M, Babnigg, J, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-07-25
公開日2014-08-20
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
1E5M
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Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.
分子名称: BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II
著者Moche, M, Edwards, P, Dehesh, K, Lindqvist, Y.
登録日2000-07-27
公開日2001-01-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献The Crystal Structure of Beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis Sp. At 1.54 A Resolution and its Relationship to Other Condensing Enzymes
J.Mol.Biol., 305, 2001
1G5X
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The Structure of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase I
分子名称: BETA-KETOACYL ACYL CARRIER PROTEIN SYNTHASE I
著者Zhang, Y.M, Rao, M.S, Heath, R.J, Price, A.C, Olson, A.J, Rock, C.O, White, S.W.
登録日2000-11-02
公開日2000-11-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
J.Biol.Chem., 276, 2001
1DD8
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CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI
分子名称: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I
著者Olsen, J.G, Kadziola, A, von Wettstein-Knowles, P, Siggaard-Andersen, M, Lindquist, Y, Larsen, S.
登録日1999-11-09
公開日1999-11-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I.
FEBS Lett., 460, 1999
1EK4
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BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH DODECANOIC ACID TO 1.85 RESOLUTION
分子名称: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I, LAURIC ACID
著者Olsen, J.G, Kadziola, A, Siggaard-Andersen, M, von Wettstein-Knowles, P, Larsen, S.
登録日2000-03-06
公開日2001-04-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
4TKT
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Streptomyces platensis isomigrastatin ketosynthase domain MgsF KS6
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AT-less polyketide synthase, CHLORIDE ION, ...
著者Chang, C, Li, H, Endres, M, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2014-05-27
公開日2014-06-11
最終更新日2023-03-22
実験手法X-RAY DIFFRACTION (2.4289 Å)
主引用文献Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
6QL6
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Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom
分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ...
著者Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
登録日2019-01-31
公開日2020-03-18
最終更新日2020-04-08
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL9
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Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom
分子名称: 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ...
著者Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
登録日2019-01-31
公開日2020-03-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6ROP
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KS-MAT DI-DOMAIN OF MOUSE FAS WITH OCTANOYL COA
分子名称: Fatty acid synthase, OCTANOIC ACID (CAPRYLIC ACID), OCTANOYL-COENZYME A
著者Paithankar, K.S, Rittner, A, Grininger, M.
登録日2019-05-13
公開日2019-12-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Type I fatty acid synthase trapped in the octanoyl-bound state.
Protein Sci., 29, 2020
6QL7
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Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom
分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17
著者Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A.
登録日2019-01-31
公開日2020-03-18
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (4.6 Å)
主引用文献Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6SMP
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AntDE:AntF (holo): type II PKS acyl-carrier protein in complex with its ketosynthase bound to the hexaketide
分子名称: (2~{R})-3,3-dimethyl-2-oxidanyl-~{N}-[3-oxidanylidene-3-[2-[(1~{R},4~{Z},6~{Z},8~{Z})-1,5,7,9-tetrakis(oxidanyl)-3,11-bis(oxidanylidene)dodeca-4,6,8-trienyl]sulfanylethylamino]propyl]-4-[tris(oxidanyl)-$l^{5}-phosphanyl]oxy-butanamide, Acyl carrier protein, Ketoacyl_synth_N domain-containing protein, ...
著者Braeuer, A, Zhou, Q, Grammbitter, G.L.C, Schmalhofer, M, Ruehl, M, Kaila, V.R.I, Bode, H, Groll, M.
登録日2019-08-22
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.
Nat.Chem., 12, 2020
6QSP
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Ketosynthase (ApeO) in Complex with its Chain Length Factor (ApeC) from Xenorhabdus doucetiae
分子名称: Beta-ketoacyl synthase, GLYCEROL, PHOSPHATE ION, ...
著者Grammbitter, G.L.C, Schmalhofer, M, Groll, M, Bode, H.
登録日2019-02-21
公開日2019-04-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments.
J.Am.Chem.Soc., 141, 2019
6RIW
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PfaC Keto synthase-Chain length factor
分子名称: MAGNESIUM ION, ORF10
著者Santin, O, Moncalian, G.
登録日2019-04-25
公開日2020-08-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase.
Biochemistry, 59, 2020
6SMO
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AntDE:AntF (apo): type II PKS acyl-carrier protein in complex with its ketosynthase bound to the hexaketide
分子名称: 3,5,7,9,11-pentakis(oxidanylidene)dodecanal, Acyl carrier protein, Ketoacyl_synth_N domain-containing protein, ...
著者Braeuer, A, Zhou, Q, Grammbitter, G.L.C, Schmalhofer, M, Ruehl, M, Kaila, V.R.I, Bode, H, Groll, M.
登録日2019-08-22
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.
Nat.Chem., 12, 2020
6TA1
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Fatty acid synthase of S. cerevisiae
分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ...
著者Vonck, J, D'Imprima, E, Joppe, M, Grininger, M.
登録日2019-10-29
公開日2019-11-06
最終更新日2020-05-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase.
Iucrj, 7, 2020
2GFW
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Structure of wild type E. coli FabF (KASII)
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2
著者Soisson, S.M, Parthasarathy, G.
登録日2006-03-23
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFX
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Structure of E. coli FabF(C163Q) in complex with Platensimycin
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN
著者Soisson, S.M, Parthasarathy, G.
登録日2006-03-23
公開日2006-05-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFY
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Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, LAURIC ACID
著者Soisson, S.M, Parthasarathy, G.
登録日2006-03-23
公開日2006-05-23
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFV
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Structure of E. coli FabF (KASII) C163Q mutant
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2
著者Soisson, S.M, Parthasarathy, G.
登録日2006-03-23
公開日2006-05-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GQD
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The crystal structure of B-ketoacyl-ACP synthase II (FabF) from Staphylococcus aureus
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2
著者Miller, D.J, White, S.W, Zhang, Y.M, Rock, C.O.
登録日2006-04-20
公開日2006-05-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of B-ketoacyl-ACP synthase II (FabF) from Staphylococcus aureus
To be Published
2IX4
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Arabidopsis thaliana mitochondrial beta-ketoacyl ACP synthase hexanoic acid complex
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, HEXANOIC ACID, POTASSIUM ION
著者Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A.
登録日2006-07-06
公開日2007-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007
2IWZ
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Human mitochondrial beta-ketoacyl ACP synthase complexed with hexanoic acid
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, AMMONIUM ION, HEXANOIC ACID
著者Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A.
登録日2006-07-05
公開日2007-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007
2IWY
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Human mitochondrial beta-ketoacyl ACP synthase
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, AMMONIUM ION
著者Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A.
登録日2006-07-05
公開日2007-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007

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