PDB: 121 件ウェブページステータス検索Chemie searchBIRD

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5ZAX	Crystal structure of thymidylate kinase in complex with ADP, TDP and TMP from thermus thermophilus HB8 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Chaudhary, S.K, Jeyakanthan, J, Sekar, K. 登録日 2018-02-09 公開日 2018-12-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Insights into product release dynamics through structural analyses of thymidylate kinase. Int. J. Biol. Macromol., 123, 2018
4NZY	Crystal structure (type-2) of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S. 登録日 2013-12-13 公開日 2014-12-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Insight into Substrate Binding Mechanism in Thymidylate Kinase based on Intrinsic Dynamics of the Active Site To be Published
3HJN	Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ... 著者 Yoshikawa, S, Nakagawa, N, Shirouzu, M, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-05-22 公開日 2009-06-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima To be Published
4XWA	TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine 分子名称: 2-(3-chlorophenoxy)-6-(ethylamino)-4-[(R)-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl](phenyl)methyl]benzoic acid, Thymidylate kinase 著者 Olivier, N.B. 登録日 2015-01-28 公開日 2015-02-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 A highly potent antibacterial inhibitor of Gram-positive bacterial thymidylate kinase (TMK): SAR of piperidinyl thymines at position C5 and L1 Bioorg Med Chem Lett, 2015
4MQB	Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, TETRAETHYLENE GLYCOL, Thymidylate kinase 著者 Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Jedrzejczak, R, Babnigg, G, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) 登録日 2013-09-16 公開日 2013-10-23 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid To be Published
6YT1	Mtb TMK crystal structure in complex with compound 26 分子名称: 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase 著者 Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N. 登録日 2020-04-23 公開日 2020-09-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur.J.Med.Chem., 206, 2020
5NR7	Mtb TMK crystal structure in complex with compound 43 分子名称: 1-[1-[[4-(3-chloranylphenoxy)quinolin-2-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase 著者 Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S. 登録日 2017-04-22 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J. Med. Chem., 61, 2018
7FGQ	Crystal structure of Thymidylate kinase with TMP and its low-resolution (SAXS) solution structure from Brugia malayi 分子名称: THYMIDINE-5'-PHOSPHATE, dTMP kinase 著者 Ramachandran, R, Vishwakarma, J, Sharma, V.K. 登録日 2021-07-27 公開日 2022-07-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Crystal structure of Thymidylate kinase with TMP and its low-resolution (SAXS) solution structure from Brugia malayi To Be Published
1TMK	YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP) 分子名称: SULFATE ION, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE 著者 Lavie, A, Schlichting, I. 登録日 1997-06-12 公開日 1998-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat.Struct.Biol., 4, 1997
5H5K	ATP and CMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, ... 著者 Biswas, A, Jeyakanthan, J, Sekar, K. 登録日 2016-11-06 公開日 2017-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
5H70	Crystal structure of ADP bound dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S. 登録日 2016-11-15 公開日 2016-12-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of ADP bound dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7 To Be Published
1GTV	CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE-5'-DIPHOSPHATE (TDP) 分子名称: ACETATE ION, MAGNESIUM ION, SULFATE ION, ... 著者 Ursby, T, Weik, M, Fioravanti, E, Delarue, M, Goeldner, M, Bourgeois, D. 登録日 2002-01-21 公開日 2002-03-28 最終更新日 2018-11-21 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals Acta Crystallogr.,Sect.D, 58, 2002
1W2G	Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Deoxythymidine (dT) (2.1 A Resolution) 分子名称: ACETATE ION, THYMIDINE, THYMIDYLATE KINASE TMK 著者 Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D. 登録日 2004-07-06 公開日 2005-01-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase in Complex with 3'-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition Biochemistry, 44, 2005
1W2H	Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Azidothymidine Monophosphate (AZT-MP) (2.0 A Resolution) 分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ACETATE ION, THYMIDYLATE KINASE TMK 著者 Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D. 登録日 2004-07-06 公開日 2005-01-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition. Biochemistry, 44, 2005
1GSI	CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP) 分子名称: ACETATE ION, MAGNESIUM ION, SULFATE ION, ... 著者 Ursby, T, Weik, M, Fioravanti, E, Delarue, M, Goeldner, M, Bourgeois, D. 登録日 2002-01-03 公開日 2002-03-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals Acta Crystallogr.,Sect.D, 58, 2002
5UIV	Structure of Thymidylate Kinase from Candida albicans Reveals Origin of Broad Substrate Specificity and a Novel Structural Element. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Bifunctional thymidylate/uridylate kinase, MAGNESIUM ION, ... 著者 Sinha, K, Rule, G.S. 登録日 2017-01-15 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 The Structure of Thymidylate Kinase from Candida albicans Reveals a Unique Structural Element. Biochemistry, 56, 2017
5TMP	COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR AZTP5A 分子名称: P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE) 著者 Lavie, A, Ostermann, N, Schlichting, I. 登録日 1998-09-01 公開日 1998-11-25 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc.Natl.Acad.Sci.USA, 95, 1998
2PBR	Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 分子名称: SULFATE ION, Thymidylate kinase 著者 Jeyakanthan, J, Kanaujia, S.P, Vasuki Ranjani, C, Sekar, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-29 公開日 2007-10-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 To be Published
5H5B	Citrate ion bound crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 分子名称: CITRATE ANION, Thymidylate kinase 著者 Biswas, A, Jeyakanthan, J, Sekar, K. 登録日 2016-11-05 公開日 2017-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
5H56	ADP and dTDP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S. 登録日 2016-11-04 公開日 2017-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
2PLR	Crystal structure of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Kanaujia, S.P, Jeyakanthan, J, Rafi, Z.A, Sekar, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-20 公開日 2008-04-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7 To be Published
4E5U	The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate. 分子名称: CALCIUM ION, THYMIDINE-5'-PHOSPHATE, Thymidylate kinase 著者 Tan, K, Joachimiak, G, Jedrzejczak, R, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) 登録日 2012-03-14 公開日 2012-03-28 実験手法 X-RAY DIFFRACTION (1.812 Å) 主引用文献 The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate. To be Published
4ESH	The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with deoxythymidine. 分子名称: THYMIDINE, Thymidylate kinase 著者 Tan, K, Joachimiak, G, Jedrzejczak, R, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) 登録日 2012-04-23 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with deoxythymidine. To be Published
3LD9	Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution 分子名称: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate kinase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-01-12 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure of thymidylate kinase from Ehrlichia chaffeensis. Acta Crystallogr.,Sect.F, 67, 2011
4F4I	Crystal structure of Thymidylate Kinase from Staphylococcus aureus in apo-form 分子名称: Thymidylate kinase 著者 Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Jedrzejczak, R, Babnigg, G, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) 登録日 2012-05-10 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of Thymidylate Kinase from Staphylococcus aureus in apo-form To be Published

 

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