PDB: 103 件ウェブページステータス検索Chemie searchBIRD

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5ABX	Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli and cap analog 分子名称: 4E-BINDING PROTEIN MEXTLI, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Peter, D, Weichenrieder, O. 登録日 2015-08-09 公開日 2015-09-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Mextli Proteins Use Both Canonical Bipartite and Novel Tripartite Binding Modes to Form Eif4E Complexes that Display Differential Sensitivity to 4E-BP Regulation Genes Dev., 29, 2015
5ABY	Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli 分子名称: 4E-BINDING PROTEIN MEXTLI, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-3, GLYCEROL, ... 著者 Peter, D, Weichenrieder, O. 登録日 2015-08-09 公開日 2015-09-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mextli Proteins Use Both Canonical Bipartite and Novel Tripartite Binding Modes to Form Eif4E Complexes that Display Differential Sensitivity to 4E-BP Regulation Genes Dev., 29, 2015
5ABV	Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli 分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GH11071P 著者 Peter, D, Weichenrieder, O. 登録日 2015-08-09 公開日 2015-09-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Mextli Proteins Use Both Canonical Bipartite and Novel Tripartite Binding Modes to Form Eif4E Complexes that Display Differential Sensitivity to 4E-BP Regulation Genes Dev., 29, 2015
5ABU	Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog 分子名称: 4E-BINDING PROTEIN MEXTLI, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, CHLORIDE ION, ... 著者 Peter, D, Weichenrieder, O. 登録日 2015-08-09 公開日 2015-09-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Mextli Proteins Use Both Canonical Bipartite and Novel Tripartite Binding Modes to Form Eif4E Complexes that Display Differential Sensitivity to 4E-BP Regulation Genes Dev., 29, 2015
5OSX	Translation initiation factor 4E in complex with m7G(5'S)ppp(5'S)G mRNA 5' cap analog 分子名称: Eukaryotic translation initiation factor 4E, POTASSIUM ION, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(3~{R},4~{S})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-phosphinic acid 著者 Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M. 登録日 2017-08-18 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc., 140, 2018
7F07	Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site. 分子名称: Eukaryotic translation initiation factor 4E, VH domain (VH-DiFCAP-01) 著者 Brown, C.J, Frosi, Y, Ng, S, Lin, Y.C. 登録日 2021-06-03 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE). Rsc Chem Biol, 3, 2022
7EZW	Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site 分子名称: ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, Eukaryotic translation initiation factor 4E, SODIUM ION 著者 Brown, C.J, Ng, S, Frosi, Y. 登録日 2021-06-02 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE). Rsc Chem Biol, 3, 2022
6FC2	Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae 分子名称: CALCIUM ION, Eukaryotic translation initiation factor 4E, Protein EAP1 著者 Gruener, S, Valkov, E. 登録日 2017-12-20 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast. Nucleic Acids Res., 46, 2018
6FC1	Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, GLYCEROL, ... 著者 Gruener, S, Valkov, E. 登録日 2017-12-20 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast. Nucleic Acids Res., 46, 2018
7KCJ	The crystal structure of the translation initiation factor EIF4E5 from Leishmania major 分子名称: Eukaryotic translation initiation factor 4E type 5 著者 Lima, G.B, Guimaraes, B.G. 登録日 2020-10-05 公開日 2021-06-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 The translation initiation factor EIF4E5 from Leishmania: crystal structure and interacting partners. Rna Biol., 18, 2021
4BEA	Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative 分子名称: Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE 著者 Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J. 登録日 2013-03-07 公開日 2013-12-11 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces. Sci.Rep., 3, 2013
4B6V	The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety 分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3 著者 Osborne, M.J, Volpon, L, Kornblatt, J.A, Culjkovic-Kraljcic, B, Baguet, A, Borden, K.L.B. 登録日 2012-08-15 公開日 2013-02-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
4B6U	Solution structure of eIF4E3 in complex with m7GDP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3 著者 Osborne, M.J, Volpon, L, Kornblatt, J.A, Culkjovic-Kraljcic, B, Baguet, A, Borden, K.L.B. 登録日 2012-08-15 公開日 2013-03-06 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition Proc.Natl.Acad.Sci.USA, 110, 2013
4AXG	Structure of eIF4E-Cup complex 分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, PROTEIN CUP 著者 Kinkelin, K, Veith, K, Gruenwald, M, Bono, F. 登録日 2012-06-12 公開日 2012-08-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of a Minimal Eif4E-Cup Complex Revelas a General Mechanism of Eif4E Regulation in Translational Repression RNA, 18, 2012
4AZA	Improved eIF4E binding peptides by phage display guided design. 分子名称: EIF4G1_D5S PEPTIDE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE 著者 Chew, W.Z, Quah, S.T, Verma, C.S, Liu, Y, Lane, D.P, Brown, C.J. 登録日 2012-06-25 公開日 2012-08-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects. Plos One, 7, 2012
5EI3	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-29 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5EKV	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-11-04 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.61 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5EHC	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-28 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5EIR	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, SULFATE ION, ... 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-30 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
4UE8	Complex of D. melanogaster eIF4E with the 4E binding protein Thor 分子名称: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 4E-BINDING PROTEIN THOR, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, ... 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
4UEB	Complex of D. melanogaster eIF4E with a designed 4E-binding protein (Form II) 分子名称: DESIGNED 4E-BP, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
4UED	Complex of human eIF4E with the 4E binding protein 4E-BP1 分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
4UEA	Complex of D. melanogaster eIF4E with a designed 4E-binding protein (Form I) 分子名称: DESIGNED 4E-BP, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
4UE9	Complex of D. melanogaster eIF4E with the 4E-binding protein 4E-T 分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
5GW6	Water-Bridge Mediates Recognition of mRNA Cap in eIF4E 分子名称: Eukaryotic translation initiation factor 4E, GLYCEROL 著者 Brown, C.J. 登録日 2016-09-08 公開日 2016-10-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Water-Bridge Mediates Recognition of mRNA Cap in eIF4E Structure, 25, 2017

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