3KED
| Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid | Descriptor: | 2,4-DIAMINOBUTYRIC ACID, Aminopeptidase N, GLYCEROL, ... | Authors: | Addlagatta, A, Gumpena, R. | Deposit date: | 2009-10-25 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases Chemmedchem, 6, 2011
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4XMX
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3FU5
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1SQM
| STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE | Descriptor: | ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ... | Authors: | Tholander, F.O.T, Rudberg, P.C, Thunnissen, M.M.G.M, Haeggstrom, J.Z. | Deposit date: | 2004-03-19 | Release date: | 2004-08-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates J.Biol.Chem., 279, 2004
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1Z5H
| Crystal structures of the Tricorn interacting Factor F3 from Thermoplasma acidophilum | Descriptor: | SULFATE ION, Tricorn protease interacting factor F3, ZINC ION | Authors: | Kyrieleis, O.J.P, Goettig, P, Kiefersauer, R, Huber, R, Brandstetter, H. | Deposit date: | 2005-03-18 | Release date: | 2005-06-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations J.MOL.BIOL., 349, 2005
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3B7T
| [E296Q]LTA4H in complex with Arg-Ala-Arg substrate | Descriptor: | IMIDAZOLE, Leukotriene A-4 hydrolase, RAR peptide, ... | Authors: | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | Deposit date: | 2007-10-31 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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2HPT
| Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, GLYCEROL, ... | Authors: | Addlagatta, A, Matthews, B.W, Gay, L. | Deposit date: | 2006-07-17 | Release date: | 2006-08-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site. Proc.Natl.Acad.Sci.Usa, 103, 2006
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8SW0
| Puromycin sensitive aminopeptidase | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Puromycin-sensitive aminopeptidase, ... | Authors: | Rodgers, D.W, Sampath, S. | Deposit date: | 2023-05-17 | Release date: | 2023-07-26 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Structure of puromycin-sensitive aminopeptidase and polyglutamine binding. Plos One, 18, 2023
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4Q4I
| Crystal structure of E.coli aminopeptidase N in complex with amastatin | Descriptor: | Amastatin, Aminopeptidase N, GLYCEROL, ... | Authors: | Reddi, R, Ganji, R.J, Addlagatta, A. | Deposit date: | 2014-04-14 | Release date: | 2015-04-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci., 24, 2015
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3FTS
| Leukotriene A4 hydrolase in complex with resveratrol | Descriptor: | ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ... | Authors: | Davies, D.R. | Deposit date: | 2009-01-13 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
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6KOY
| Crystal structure of two domain M1 Zinc metallopeptidase E323A mutant bound to L-tryptophan amino acid | Descriptor: | TRYPTOPHAN, ZINC ION, Zinc metalloprotease | Authors: | Agrawal, R, Kumar, A, Kumar, A, Makde, R.D. | Deposit date: | 2019-08-13 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase. Int.J.Biol.Macromol., 147, 2020
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8QOW
| LTA4 hydrolase in complex with compound 2(S) | Descriptor: | (2~{S})-2-azanyl-3-[3-[4-[3-fluoranyl-5-(1~{H}-pyrazol-5-yl)pyridin-2-yl]oxyphenyl]pyrazol-1-yl]propan-1-ol, ACETATE ION, IMIDAZOLE, ... | Authors: | Srinivas, H. | Deposit date: | 2023-09-29 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. J.Med.Chem., 66, 2023
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6U7G
| HCoV-229E RBD Class V in complex with human APN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | Authors: | Tomlinson, A, Li, Z, Rini, J.M. | Deposit date: | 2019-09-02 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
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6G8B
| E. coli Aminopeptidase N solved by Native SAD from a dataset collected in 60 second with JUNGFRAU detector | Descriptor: | Aminopeptidase N, DIMETHYL SULFOXIDE, SODIUM ION, ... | Authors: | Leonarski, F, Olieric, V, Redford, S, Wang, M. | Deposit date: | 2018-04-08 | Release date: | 2018-08-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.374 Å) | Cite: | Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector. Nat. Methods, 15, 2018
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3FUE
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3FUL
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4XNA
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4KXB
| Crystal structure of human aminopeptidase A complexed with bestatin | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, Y, Liu, C, Lin, Y.Y, Li, F. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
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4KX8
| Crystal structure of human aminopeptidase A complexed with amastatin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, Y, Liu, C, Lin, Y.Y, Li, F. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
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4KXA
| Crystal structure of human aminopeptidase A complexed with aspartate and calcium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, Y, Liu, C, Lin, Y.Y, Li, F. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
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4KXC
| Crystal structure of human aminopeptidase A complexed with glutamate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, Y, Liu, C, Lin, Y.Y, Li, F. | Deposit date: | 2013-05-25 | Release date: | 2013-07-31 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
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6EA4
| ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Maben, Z, Stern, L.J. | Deposit date: | 2018-08-02 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of human ER aminopeptidase 1 bound to aryl sulfonamide inhibitor. To Be Published
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5AB0
| Crystal structure of aminopeptidase ERAP2 with ligand | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mpakali, A, Giastas, P, Saridakis, E, Stratikos, E. | Deposit date: | 2015-07-31 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
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5YO1
| Structure of ePepN E298A mutant in complex with Puromycin | Descriptor: | Aminopeptidase N, GLYCEROL, PUROMYCIN, ... | Authors: | Ganji, R.J, Reddi, R, Marapaka, A.K, Addlagatta, A. | Deposit date: | 2017-10-26 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Puromycin, a selective inhibitor of PSA acts as a substrate for other M1 family aminopeptidases: Biochemical and structural basis Int.J.Biol.Macromol., 165, 2020
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5LG6
| Structure of the deglycosylated porcine aminopeptidase N ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ZINC ION | Authors: | Santiago, C, Reguera, J, Mudgal, G, Casasnovas, J.M. | Deposit date: | 2016-07-06 | Release date: | 2017-04-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. Sci Rep, 7, 2017
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