8QOW
LTA4 hydrolase in complex with compound 2(S)
Summary for 8QOW
| Entry DOI | 10.2210/pdb8qow/pdb |
| Related | 7AUZ |
| Descriptor | Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total) |
| Functional Keywords | lta4h, inhibitors, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 70447.10 |
| Authors | Srinivas, H. (deposition date: 2023-09-29, release date: 2023-12-06, Last modification date: 2023-12-27) |
| Primary citation | Thoma, G.,Markert, C.,Lueoend, R.,Miltz, W.,Spanka, C.,Bollbuck, B.,Wolf, R.M.,Srinivas, H.,Penno, C.A.,Kiffe, M.,Gajewska, M.,Bednarczyk, D.,Wieczorek, G.,Evans, A.,Beerli, C.,Rohn, T.A. Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. J.Med.Chem., 66:16410-16425, 2023 Cited by PubMed: 38015154DOI: 10.1021/acs.jmedchem.3c01866 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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