8A28
| |
7UAI
| Meprin alpha helix in complex with fetuin-B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-13 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
|
|
7UAB
| Human pro-meprin alpha (zymogen state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-12 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
|
|
7UAC
| Human pro-meprin alpha (zymogen state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Meprin A subunit alpha, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-12 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
|
|
7UAE
| Human meprin alpha (active state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-12 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
|
|
7UAF
| Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-12 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
|
|
7AUW
| Inhibitory complex of human meprin beta with mouse fetuin-B. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fetuin-B, ... | 著者 | Eckhard, U, Gomis-Ruth, F.X. | 登録日 | 2020-11-03 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin beta by endogenous fetuin-B. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7AQ1
| Crystal structure of human mature meprin beta in complex with the specific inhibitor MWT-S-270 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Linnert, M, Parthier, C, Fritz, C. | 登録日 | 2020-10-20 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.413 Å) | 主引用文献 | Structure and Dynamics of Meprin beta in Complex with a Hydroxamate-Based Inhibitor. Int J Mol Sci, 22, 2021
|
|
6SAZ
| Cleaved human fetuin-b in complex with crayfish astacin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ... | 著者 | Gomis-Ruth, F.X, Guevara, T, Cuppari, A, Korschgen, H, Schmitz, C, Kuske, M, Yiallouros, I, Floehr, J, Jahnen-Dechent, W, Stocker, W. | 登録日 | 2019-07-18 | 公開日 | 2019-10-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases. Sci Rep, 9, 2019
|
|
6HT9
| Mouse fetuin-B in complex with crayfish astacin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ... | 著者 | Gomis-Ruth, F.X, Goulas, T, Guevara, T, Cuppari, A. | 登録日 | 2018-10-03 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition. Iucrj, 6, 2019
|
|
5ZJK
| Structure of myroilysin | 分子名称: | Myroilysin, PHOSPHATE ION, ZINC ION | 著者 | Li, W.D, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2018-03-20 | 公開日 | 2019-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of mature myroilysin and implication for its activation mechanism. Int.J.Biol.Macromol., 2019
|
|
6BTP
| BMP1 complexed with a hydroxamate | 分子名称: | (1R,3S,4S)-2-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]heptanoyl}-N-(3-methoxypyrazin-2-yl)-2-azabicyclo[2.2.1]heptane-3-carboxamide, Bone morphogenetic protein 1, THIOCYANATE ION, ... | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
6BTQ
| BMP1 complexed with a hydroxamate - compound 2 | 分子名称: | 1,2-ETHANEDIOL, Bone morphogenetic protein 1, N~2~-[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]-3-thiophen-2-yl-D-alaninamide, ... | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
6BTO
| BMP1 complexed with (2~{S})-2-[[(1~{R},3~{S},4~{S})-2-[(2~{R})-2-[2-(oxidanylamino)-2-oxidanylidene-ethyl]heptanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]carbonylamino]-2-phenyl-ethanoic acid | 分子名称: | (2~{S})-2-[[(1~{R},3~{S},4~{S})-2-[(2~{R})-2-[2-(oxidanylamino)-2-oxidanylidene-ethyl]heptanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]carbonylamino]-2-phenyl-ethanoic acid, 1,2-ETHANEDIOL, Bone morphogenetic protein 1, ... | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
6BTN
| BMP1 complexed with a reverse hydroxymate - compound 1 | 分子名称: | (3S)-6-cyclohexyl-3-{3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl}-N-hydroxyhexanamide, 1,2-ETHANEDIOL, Bone morphogenetic protein 1, ... | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
6BSL
| BMP1 complexed with a reverse hydroxymate - compound 22 | 分子名称: | 1,2-ETHANEDIOL, Bone morphogenetic protein 1, N-(2-ethoxy-4-{5-[({[(2R)-2-{(1R)-1-[formyl(hydroxy)amino]propyl}heptanoyl]amino}methyl)carbamoyl]furan-2-yl}benzene-1-carbonyl)-L-aspartic acid, ... | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-04 | 公開日 | 2018-08-08 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
6BSM
| BMP1 complexed with a reverse hydroxamate - compound 4 | 分子名称: | Bone morphogenetic protein 1, N-({[(2R)-2-{[hydroxy(hydroxymethyl)amino]methyl}heptanoyl]amino}methyl)-7-methoxy-1-benzofuran-2-carboxamide, ZINC ION | 著者 | Gampe, R, Shewchuk, L. | 登録日 | 2017-12-04 | 公開日 | 2018-08-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9, 2018
|
|
5GWD
| Structure of Myroilysin | 分子名称: | Myroilysin, ZINC ION | 著者 | Xu, D, Ran, T, Wang, W. | 登録日 | 2016-09-10 | 公開日 | 2017-02-15 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. J. Biol. Chem., 292, 2017
|
|
5CZW
| Crystal structure of myroilysin | 分子名称: | Myroilysin, ZINC ION | 著者 | Zhou, J, Ran, T, Xu, D, Wang, W. | 登録日 | 2015-08-01 | 公開日 | 2016-08-03 | 最終更新日 | 2017-04-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism J. Biol. Chem., 292, 2017
|
|
4GWM
| Crystal structure of human promeprin beta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Arolas, J.L, Broder, C, Jefferson, T, Guevara, T, Sterchi, E.E, Bode, W, Stocker, W, Becker-Pauly, C, Gomis-Ruth, F.X. | 登録日 | 2012-09-03 | 公開日 | 2012-09-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4GWN
| Crystal structure of human mature meprin beta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Arolas, J.L, Broder, C, Jefferson, T, Guevara, T, Sterchi, E.E, Bode, W, Stocker, W, Becker-Pauly, C, Gomis-Ruth, F.X. | 登録日 | 2012-09-03 | 公開日 | 2012-09-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
3VTG
| High choriolytic enzyme 1 (HCE-1), a hatching enzyme zinc-protease from Oryzias latipes (Medaka fish) | 分子名称: | High choriolytic enzyme 1, ZINC ION | 著者 | Kudo, N, Yasumasu, S, Iuchi, I, Tanokura, M. | 登録日 | 2012-05-30 | 公開日 | 2013-06-05 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Crystal Structure of High choriolytic enzyme 1 (HCE-1), a hatching enzyme from Oryzias latipes (Medaka fish) To be Published
|
|
3LQB
| Crystal structure of the hatching enzyme ZHE1 from the zebrafish Danio rerio | 分子名称: | 1,2-ETHANEDIOL, LOC792177 protein, SULFATE ION, ... | 著者 | Tanokura, M, Okada, A, Nagata, K, Yasumasu, S, Ohtsuka, J, Iuchi, I. | 登録日 | 2010-02-08 | 公開日 | 2010-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio J.Mol.Biol., 402, 2010
|
|
3LQ0
| Zymogen structure of crayfish astacin metallopeptidase | 分子名称: | GLYCEROL, ProAstacin, SULFATE ION, ... | 著者 | Guevara, T, Yiallouros, I, Kappelhoff, R, Bissdorf, S, Stocker, W, Gomis-Ruth, F.X. | 登録日 | 2010-02-08 | 公開日 | 2010-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Proenzyme structure and activation of astacin metallopeptidase J.Biol.Chem., 285, 2010
|
|
3EDI
| |