6BSM

BMP1 complexed with a reverse hydroxamate - compound 4

Summary for 6BSM

Entry DOI	10.2210/pdb6bsm/pdb
Descriptor	Bone morphogenetic protein 1, ZINC ION, N-({[(2R)-2-{[hydroxy(hydroxymethyl)amino]methyl}heptanoyl]amino}methyl)-7-methoxy-1-benzofuran-2-carboxamide, ... (4 entities in total)
Functional Keywords	endopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	23463.31
Authors	Gampe, R.,Shewchuk, L. (deposition date: 2017-12-04, release date: 2018-08-08)
Primary citation	Kallander, L.S.,Washburn, D.,Hilfiker, M.A.,Eidam, H.S.,Lawhorn, B.G.,Prendergast, J.,Fox, R.,Dowdell, S.,Manns, S.,Hoang, T.,Zhao, S.,Ye, G.,Hammond, M.,Holt, D.A.,Roethke, T.,Hong, X.,Reid, R.A.,Gampe, R.,Zhang, H.,Diaz, E.,Rendina, A.R.,Quinn, A.M.,Willette, B. Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett, 9:736-740, 2018 Cited by PubMed: 30034610 DOI: 10.1021/acsmedchemlett.8b00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation