7LVB
 
 | | CHOLERA TOXIN B SUBUNIT WITH ATTACHED SIV EPITOPE | | 分子名称: | CHLORIDE ION, Cholera enterotoxin B-subunit,Surface protein gp120, TRIETHYLENE GLYCOL, ... | | 著者 | Patskovsky, Y, Cardozo, T.J. | | 登録日 | 2021-02-24 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV mac251 acquisition in macaques.
Front Immunol, 14, 2023
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6IAL
 | | Porcine E.coli heat-labile enterotoxin B-pentamer in complex with Lacto-N-neohexaose | | 分子名称: | CALCIUM ION, GLYCEROL, Heat-labile enterotoxin B chain, ... | | 著者 | Heim, J.B, Heggelund, J.E, Krengel, U. | | 登録日 | 2018-11-27 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Specificity ofEscherichia coliHeat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography.
Int J Mol Sci, 20, 2019
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6HSV
 | | Engineered higher-order assembly of Cholera Toxin B subunits via the addition of C-terminal parallel coiled-coiled domains | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... | | 著者 | Pearson, A.R, Turnbull, W.B, Ross, J.F, Trinh, C.H, Webb, M.E. | | 登録日 | 2018-10-01 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages.
J.Am.Chem.Soc., 141, 2019
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6HMW
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6HMY
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6HJD
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5LZH
 | | Cholera toxin classical B-pentamer in complex with inhibitor PC262 | | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Heggelund, J.E, Martinsen, T, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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5LZJ
 | | Cholera toxin El Tor B-pentamer in complex with inhibitor Laura237 | | 分子名称: | (~{Z})-~{N}-[2-[(2~{R},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide, Cholera enterotoxin subunit B, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Heggelund, J.E, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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5LZG
 | | Cholera toxin El Tor B-pentamer in complex with inhibitor PC262 | | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Heggelund, J.E, Martinsen, T, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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5LZI
 | | Porcine heat-labile enterotoxin R13H in complex with inhibitor MM146 | | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[(2~{R})-3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-2-(2-phenylethanoylamino)propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[(2~{S})-3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-2-(2-phenylethanoylamino)propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Heggelund, J.E, Mackenzie, A, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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5ELD
 | | Cholera toxin classical B-pentamer in complex with A Lewis-y | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cholera enterotoxin B subunit, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Heggelund, J.E, Burschowsky, D, Krengel, U. | | 登録日 | 2015-11-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Plos Pathog., 12, 2016
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5ELF
 | | Cholera toxin El Tor B-pentamer in complex with A-pentasaccharide | | 分子名称: | BICINE, CALCIUM ION, Cholera enterotoxin subunit B, ... | | 著者 | Heggelund, J.E, Burschowsky, D, Krengel, U. | | 登録日 | 2015-11-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Plos Pathog., 12, 2016
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5ELB
 | | Cholera toxin classical B-pentamer in complex with Lewis-y | | 分子名称: | BICINE, CALCIUM ION, Cholera enterotoxin B subunit, ... | | 著者 | Heggelund, J.E, Burschowsky, D, Krengel, U. | | 登録日 | 2015-11-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Plos Pathog., 12, 2016
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5ELC
 | | Cholera toxin El Tor B-pentamer in complex with Lewis-y | | 分子名称: | BICINE, CALCIUM ION, Cholera enterotoxin subunit B, ... | | 著者 | Heggelund, J.E, Burschowsky, D, Krengel, U. | | 登録日 | 2015-11-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Plos Pathog., 12, 2016
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5ELE
 | | Cholera toxin El Tor B-pentamer in complex with A Lewis-y | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICINE, CALCIUM ION, ... | | 著者 | Heggelund, J.E, Burschowsky, D, Krengel, U. | | 登録日 | 2015-11-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Plos Pathog., 12, 2016
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4L6T
 | | GM1 bound form of the ECX AB5 holotoxin | | 分子名称: | ECXA, ECXB, ZINC ION, ... | | 著者 | Littler, D.R, Ng, N.M, Rossjohn, J, Beddoe, T. | | 登録日 | 2013-06-12 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | | 主引用文献 | EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
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4L63
 | | Apo form of AB5 holotoxin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ECXA, ECXB, ... | | 著者 | Littler, D.R, Ng, N.M, Rossjohn, J, Beddoe, T. | | 登録日 | 2013-06-11 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
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2XRS
 | | Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin | | 分子名称: | HEAT-LABILE ENTEROTOXIN B CHAIN, beta-D-galactopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Holmner, A, Mackenzie, A, Okvist, M, Jansson, L, Lebens, M, Teneberg, S, Krengel, U. | | 登録日 | 2010-09-20 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia Coli Heat-Labile Enterotoxin Compared to Cholera Toxin
J.Mol.Biol., 406, 2011
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2XRQ
 | | Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin | | 分子名称: | HEAT-LABILE ENTEROTOXIN B CHAIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Holmner, A, Mackenzie, A, Okvist, M, Jansson, L, Lebens, M, Teneberg, S, Krengel, U. | | 登録日 | 2010-09-19 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia Coli Heat-Labile Enterotoxin Compared to Cholera Toxin
J.Mol.Biol., 406, 2011
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2WV6
 | | Crystal structure of the cholera toxin-like B-subunit from Citrobacter freundii to 1.9 angstrom | | 分子名称: | 1,2-ETHANEDIOL, CFXB, GLYCEROL | | 著者 | Jansson, L, Lebens, M, Imberty, A, Varrot, A, Teneberg, S. | | 登録日 | 2009-10-15 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.895 Å) | | 主引用文献 | Carbohydrate Binding Specificities and Crystal Structure of the Cholera Toxin-Like B-Subunit from Citrobacter Freundii.
Biochimie, 92, 2010
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3EFX
 | | Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin, 1.9A crystal structure reveals the details | | 分子名称: | Cholera enterotoxin subunit B, Heat-labile enterotoxin B chain, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]beta-D-glucopyranose | | 著者 | Holmner, A, Lebens, M, Teneberg, S, Angstrom, J, Okvist, M, Krengel, U. | | 登録日 | 2008-09-10 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the details
Structure, 12, 2004
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2O2L
 | | Crystal structure of human heat-labile enterotoxin in complex with a blood group A antigen analog | | 分子名称: | Heat-labile enterotoxin B chain, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]beta-D-glucopyranose | | 著者 | Holmner, A, Askarieh, G, Okvist, M, Krengel, U. | | 登録日 | 2006-11-30 | | 公開日 | 2007-08-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Blood Group Antigen Recognition by Escherichia coli Heat-labile Enterotoxin
J.Mol.Biol., 371, 2007
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1S5C
 | | Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1 | | 分子名称: | Cholera enterotoxin, A chain, SODIUM ION, ... | | 著者 | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | | 登録日 | 2004-01-20 | | 公開日 | 2004-04-06 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of an intrinsically active cholera toxin mutant yield
insight into the toxin activation mechanism
Biochemistry, 43, 2004
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1S5D
 | | Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 2 | | 分子名称: | Cholera enterotoxin, A chain, GLYCEROL, ... | | 著者 | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | | 登録日 | 2004-01-20 | | 公開日 | 2004-04-06 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structures of an intrinsically active cholera toxin
mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
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1S5F
 | | Cholera holotoxin, Crystal form 2 | | 分子名称: | Cholera enterotoxin, A chain, SODIUM ION, ... | | 著者 | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | | 登録日 | 2004-01-20 | | 公開日 | 2004-04-06 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
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