7LVB

CHOLERA TOXIN B SUBUNIT WITH ATTACHED SIV EPITOPE

Summary for 7LVB

• Entry DOI: 10.2210/pdb7lvb/pdb
• Descriptor: Cholera enterotoxin B-subunit,Surface protein gp120, beta-D-galactopyranose, TRIETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: toxin, cholera toxin, lectin, complex, galactose, simian immunodeficiency virus, immune epitope
• Biological source: Vibrio cholerae; More
• Total number of polymer chains: 10
• Total formula weight: 138996.38

Authors

Patskovsky, Y.,Cardozo, T.J. (deposition date: 2021-02-24, release date: 2022-03-02, Last modification date: 2023-10-18)

Primary citation

Rahman, M.A.,Becerra-Flores, M.,Patskovsky, Y.,Silva de Castro, I.,Bissa, M.,Basu, S.,Shen, X.,Williams, L.D.,Sarkis, S.,N'guessan, K.F.,LaBranche, C.,Tomaras, G.D.,Aye, P.P.,Veazey, R.,Paquin-Proulx, D.,Rao, M.,Franchini, G.,Cardozo, T.
Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV mac251 acquisition in macaques.
Front Immunol, 14:1139402-1139402, 2023

PubMed Abstract: An efficacious HIV vaccine will need to elicit a complex package of innate, humoral, and cellular immune responses. This complex package of responses to vaccine candidates has been studied and yielded important results, yet it has been a recurring challenge to determine the magnitude and protective effect of specific immune responses in isolation. We therefore designed a single, viral-spike-apical, epitope-focused V2 loop immunogen to reveal individual vaccine-elicited immune factors that contribute to protection against HIV/SIV.

PubMed: 37153584
DOI: 10.3389/fimmu.2023.1139402

Experimental method

X-RAY DIFFRACTION (2.25 Å)