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1TVZ
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Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Staphylococcus aureus
分子名称: 3-hydroxy-3-methylglutaryl-CoA synthase, SULFATE ION
著者Campobasso, N, Patel, M, Wilding, I.E, Kallender, H, Rosenberg, M, Gwynn, M.
登録日2004-06-30
公開日2004-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
J.Biol.Chem., 279, 2004
1TXT
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Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase
分子名称: 3-hydroxy-3-methylglutaryl-CoA synthase, ACETOACETYL-COENZYME A
著者Campobasso, N, Patel, M, Wilding, I.E, Kallender, H, Rosenberg, M, Gwynn, M.
登録日2004-07-06
公開日2004-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
J.Biol.Chem., 279, 2004
1X9E
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Crystal structure of HMG-CoA synthase from Enterococcus faecalis
分子名称: HMG-CoA synthase, SULFATE ION
著者Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
登録日2004-08-20
公開日2005-11-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
1XPL
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Crystal Structure of Staphylococcus aureus HMG-COA Synthase with Acetoacetyl-COA and Acetylated Cysteine
分子名称: 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, SULFATE ION
著者Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T.
登録日2004-10-08
公開日2004-11-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPM
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Crystal Structure of Staphylococcus aureus HMG-COA Synthase with HMG-CoA and Acetoacetyl-COA and Acetylated Cysteine
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, ...
著者Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T.
登録日2004-10-08
公開日2004-11-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPK
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-CoA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, ...
著者Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T.
登録日2004-10-08
公開日2004-11-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1YSL
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Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand.
分子名称: ACETOACETIC ACID, COENZYME A, GLYCEROL, ...
著者Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
登録日2005-02-08
公開日2005-11-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
2F82
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HMG-CoA synthase from Brassica juncea in the apo-form
分子名称: HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-01
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F9A
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HMG-CoA synthase from Brassica juncea in complex with F-244
分子名称: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, 3-Hydroxy-3-methylglutaryl coenzyme A synthase 1
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-05
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA0
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HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-06
公開日2006-07-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA3
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HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.
分子名称: ACETYL COENZYME *A, HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-06
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HDB
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HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HMG-CoA synthase, SULFATE ION
著者Steussy, C.N, Sutherlin, A, Stauffacher, C.V.
登録日2006-06-20
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006
2P8U
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Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I
分子名称: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
著者Turnbull, A, Shafqat, N, Salah, E, Niesen, F.H, Burgess, N, Bunkoczi, G, Debreczeni, J, Pike, A.C.W, Umeano, C, Gorrec, F, von Delft, F, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2007-03-23
公開日2007-04-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol., 398, 2010
2WYA
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, HYDROXYMETHYLGLUTARYL-COA SYNTHASE, ...
著者Yue, W.W, Shafqat, N, Savitsky, P, Roos, A.K, Cooper, C, Murray, J.W, von Delft, F, Arrowsmith, C, Wikstrom, M, Edwards, A, Bountra, C, Oppermann, U.
登録日2009-11-13
公開日2009-11-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
3V4X
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The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin
分子名称: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, HMG-CoA synthase
著者Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M.
登録日2011-12-15
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.952 Å)
主引用文献Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
3V4N
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The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HMG-CoA synthase
著者Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M.
登録日2011-12-15
公開日2012-04-25
最終更新日2014-09-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
4YXT
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PksG, a HMG-CoA Synthase from Bacillus subtilus
分子名称: Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
著者Till, M, Nair, A.V, Robson, A, Race, P.R.
登録日2015-03-23
公開日2016-06-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
4YXQ
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PksG, a HMG-CoA Synthase from Bacillus subtilis
分子名称: DI(HYDROXYETHYL)ETHER, Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
著者Nair, A.V, Race, P.R, Till, M.
登録日2015-03-23
公開日2016-06-29
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献PksG, a HMG-CoA Synthase from Bacillus subtilis
To Be Published
4YXV
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PksG, a HMG-CoA Synthase from Bacillus subtilus
分子名称: Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
著者Till, M, Nair, A.V, Robson, A, Race, P.R.
登録日2015-03-23
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
5HWO
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MvaS in complex with 3-hydroxy-3-methylglutaryl coenzyme A
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
著者Bock, T, Kasten, J, Blankenfeldt, W.
登録日2016-01-29
公開日2016-05-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWP
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MvaS with acetylated Cys115 in complex with coenzyme A
分子名称: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
著者Bock, T, Kasten, J, Blankenfeldt, W.
登録日2016-01-29
公開日2016-05-11
最終更新日2016-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWQ
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MvaS in complex with acetoacetyl coenzyme A
分子名称: ACETOACETYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
著者Bock, T, Kasten, J, Blankenfeldt, W.
登録日2016-01-29
公開日2016-05-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWR
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MvaS in complex with coenzyme A
分子名称: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
著者Bock, T, Kasten, J, Blankenfeldt, W.
登録日2016-01-29
公開日2016-05-11
最終更新日2016-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5KP7
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Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Holo Donor-ACP
分子名称: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ...
著者Maloney, F.P, Smith, J.L.
登録日2016-07-02
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP8
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Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Acetyl Donor-ACP
分子名称: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ...
著者Maloney, F.P, Smith, J.L.
登録日2016-07-02
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016

 

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