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4JX5	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with pyruvate Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... Authors: Lietzan, A.D, St Maurice, M. Deposit date: 2013-03-27 Release date: 2013-05-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase. J.Biol.Chem., 288, 2013
4JX6	Structure of the carboxyl transferase domain Y628A from Rhizobium etli pyruvate carboxylase with pyruvate Descriptor: GLYCEROL, MAGNESIUM ION, PYRUVIC ACID, ... Authors: Lietzan, A.D, St Maurice, M. Deposit date: 2013-03-27 Release date: 2013-05-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.78 Å) Cite: A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase. J.Biol.Chem., 288, 2013
4LOC	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with oxamate and biotin Descriptor: BIOTIN, CHLORIDE ION, GLYCEROL, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-07-12 Release date: 2014-09-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.26 Å) Cite: The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase. Arch.Biochem.Biophys., 562C, 2014
4LRS	Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, CHLORIDE ION, ... Authors: Fischer, B, Branlant, G, Talfournier, F, Gruez, A. Deposit date: 2013-07-20 Release date: 2013-09-04 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site To be Published
4LRT	Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, COENZYME A, ... Authors: Fischer, B, Branlant, G, Talfournier, F, Gruez, A. Deposit date: 2013-07-20 Release date: 2013-09-04 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site To be Published
4M6V	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with pyruvate and biocytin Descriptor: Biocytin, CHLORIDE ION, GLYCEROL, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-08-11 Release date: 2014-09-10 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase. Arch.Biochem.Biophys., 562C, 2014
4MFD	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with oxalate Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-08-27 Release date: 2013-11-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. Biochem.Biophys.Res.Commun., 441, 2013
4MFE	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with 3-hydroxypyruvate Descriptor: 3-HYDROXYPYRUVIC ACID, BIOTIN, CHLORIDE ION, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-08-27 Release date: 2013-11-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. Biochem.Biophys.Res.Commun., 441, 2013
4MIM	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with 3-bromopyruvate Descriptor: Bromopyruvate, CHLORIDE ION, GLYCEROL, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-09-01 Release date: 2014-08-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. Biochem.Biophys.Res.Commun., 441, 2013
4OV4	Isopropylmalate synthase binding with ketoisovalerate Descriptor: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, ZINC ION Authors: Zhang, Z, Wu, J, Wang, C, Zhang, P. Deposit date: 2014-02-20 Release date: 2014-08-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
4OV9	Structure of isopropylmalate synthase binding with alpha-isopropylmalate Descriptor: (2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid, ZINC ION, isopropylmalate synthase Authors: Zhang, Z, Wu, J, Wang, C, Zhang, P. Deposit date: 2014-02-20 Release date: 2014-08-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
5KS8	Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, PYRUVIC ACID, ... Authors: Choi, P.H, Tong, L. Deposit date: 2016-07-07 Release date: 2016-10-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.01 Å) Cite: A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun, 7, 2016
6E1J	Crystal Structure of Methylthioalkylmalate Synthase (BjuMAM1.1) from Brassica juncea Descriptor: 2-isopropylmalate synthase, A genome specific 1, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, ... Authors: Lee, S.G, Jez, J.M. Deposit date: 2018-07-09 Release date: 2019-05-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Molecular Basis of the Evolution of Methylthioalkylmalate Synthase and the Diversity of Methionine-Derived Glucosinolates. Plant Cell, 31, 2019
6KTQ	Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA Descriptor: 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... Authors: Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. Deposit date: 2019-08-28 Release date: 2020-09-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius. Febs J., 288, 2021
6NDS	Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate Descriptor: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl-CoA lyase, ACETATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-12-14 Release date: 2019-12-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate to be published
7WTA	Cryo-EM structure of human pyruvate carboxylase in apo state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTB	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTC	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (4 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTD	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTE	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2 Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7ZYY	Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.12 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZYZ	Cryo-EM structure of "CT oxa" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MANGANESE (II) ION, OXALOACETATE ION, Pyruvate carboxylase Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.47 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ0	Cryo-EM structure of "CT empty" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Pyruvate carboxylase Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.26 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ1	Cryo-EM structure of "CT react" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: BIOTIN, MAGNESIUM ION, MANGANESE (II) ION, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.27 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ2	Cryo-EM structure of "CT pyr" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MAGNESIUM ION, MANGANESE (II) ION, PYRUVIC ACID, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022

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