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8I4C
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Cryo-EM structure of U46619-bound ABCC4
分子名称: (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, ATP-binding cassette sub-family C member 4
著者Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q.
登録日2023-01-19
公開日2023-05-24
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
8I4A
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Cryo-EM structure of dipyridamole-bound ABCC4
分子名称: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, ATP-binding cassette sub-family C member 4
著者Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q.
登録日2023-01-19
公開日2023-05-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
8HW2
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Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs
分子名称: ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-28
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HW4
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Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs
分子名称: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-28
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HVH
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Cryo-EM structure of ABC transporter ABCC3
分子名称: ATP-binding cassette sub-family C member 3
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-26
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8TI1
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BU of 8ti1 by Molmil
Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-sensitive inward rectifier potassium channel 11, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Driggers, C.M, Shyng, S.-L.
登録日2023-07-18
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
Nat Commun, 15, 2024
8SG4
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E1435Q Ycf1 mutant in dephosphorylated state
分子名称: Metal resistance protein YCF1
著者Khandelwal, N.K, Tomasiak, T.M.
登録日2023-04-11
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献E1435Q Ycf1 mutant in dephosphorylated state
To Be Published
8WOO
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BU of 8woo by Molmil
Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state
分子名称: ABC transporter B family member 19, Brassinolide, MAGNESIUM ION, ...
著者Ying, W, Wei, H, Liu, X, Sun, L.
登録日2023-10-07
公開日2024-03-13
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
8TI2
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Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-sensitive inward rectifier potassium channel 11, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
著者Driggers, C.M, Shyng, S.-L.
登録日2023-07-18
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
Nat Commun, 15, 2024
8WP0
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Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state
分子名称: ABC transporter B family member 19, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Ying, W, Wei, H, Liu, X, Sun, L.
登録日2023-10-08
公開日2024-03-13
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
8T1P
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Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ...
著者Tang, Q, Mchaourab, H.S.
登録日2023-06-02
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8UBR
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Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Young, P.G, Fiedorczuk, K, Chen, J.
登録日2023-09-24
公開日2024-02-21
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
8SZC
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-1HT/ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Tang, Q, Mchaourab, H.
登録日2023-05-29
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8T3K
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ...
著者Tang, Q, Mchaourab, H.
登録日2023-06-07
公開日2023-11-29
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8WOM
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BU of 8wom by Molmil
Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state
分子名称: ABC transporter B family member 19, Brassinolide
著者Ying, W, Wei, H, Liu, X, Sun, L.
登録日2023-10-07
公開日2024-03-13
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
8WOI
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Structure of the wild-type Arabidopsis ABCB19 in the apo state
分子名称: ABC transporter B family member 19
著者Ying, W, Wei, H, Liu, X, Sun, L.
登録日2023-10-07
公開日2024-03-13
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
8SWN
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BU of 8swn by Molmil
Bovine multidrug resistance protein 4 (MRP4) E1202Q mutant bound to ATP in MSP lipid nanodisc
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP binding cassette subfamily C member 4, MAGNESIUM ION, ...
著者Pourmal, S, Stroud, R.M.
登録日2023-05-19
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
8SX9
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BU of 8sx9 by Molmil
Inward-facing narrow conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc
分子名称: Multidrug resistance-associated protein 4
著者Pourmal, S, Stroud, R.M.
登録日2023-05-20
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
8SXB
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Bovine multidrug resistance protein 4 (MRP4) bound to prostaglandin E2 in MSP lipid nanodisc
分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Multidrug resistance-associated protein 4 isoform X1
著者Pourmal, S, Stroud, R.M.
登録日2023-05-20
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
8SXA
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BU of 8sxa by Molmil
Inward-facing wide conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc
分子名称: Multidrug resistance-associated protein 4
著者Pourmal, S, Stroud, R.M.
登録日2023-05-20
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
8SX8
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Bovine multidrug resistance protein 4 (MRP4) bound to prostaglandin E1 in MSP lipid nanodisc
分子名称: 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, Multidrug resistance-associated protein 4
著者Pourmal, S, Stroud, R.M.
登録日2023-05-20
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
8SX7
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Bovine multidrug resistance protein 4 (MRP4) bound to DHEA-S in MSP lipid nanodisc
分子名称: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, Multidrug resistance-associated protein 4
著者Pourmal, S, Stroud, R.M.
登録日2023-05-20
公開日2024-01-17
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of prostaglandin efflux by MRP4.
Nat.Struct.Mol.Biol., 2024
6PZC
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BU of 6pzc by Molmil
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine
分子名称: ATP-binding cassette sub-family C member 8
著者Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W.
登録日2019-07-31
公開日2019-08-14
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.34 Å)
主引用文献Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
6QEX
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Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Alam, A, Locher, K.P.
登録日2019-01-08
公開日2019-02-27
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science, 363, 2019
6QV2
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Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2
分子名称: ABC transporter, ATP-binding protein, MAGNESIUM ION, ...
著者Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A.
登録日2019-03-01
公開日2019-05-29
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (4.23 Å)
主引用文献The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019

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件を2024-04-24に公開中

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