8TA6
 
 | | Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain | | 分子名称: | Chloride channel protein 2 | | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | | 登録日 | 2023-06-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
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8TA5
 | | Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal | | 分子名称: | Chloride channel protein 2 | | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | | 登録日 | 2023-06-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
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8TA4
 | | Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal | | 分子名称: | CHLORIDE ION, Chloride channel protein 2 | | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | | 登録日 | 2023-06-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
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8TA3
 | | Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin | | 分子名称: | CHLORIDE ION, Chloride channel protein 2 | | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | | 登録日 | 2023-06-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
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8TA2
 | | Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42 | | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2 | | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | | 登録日 | 2023-06-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
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8JPR
 | | Cryo-EM structure of Y553C human ClC-6 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ... | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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8JPO
 | | Cryo-EM structure of ATP bound human ClC-6 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ... | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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8JPJ
 | | Cryo-EM structure of ClC-6 apo state | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter 6 | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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8IAD
 | | The Arabidopsis CLCa transporter bound with nitrate, ATP and PIP2 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | | 著者 | Yang, Z, Zhang, X, Zhang, P. | | 登録日 | 2023-02-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
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8IAB
 | | The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ... | | 著者 | Yang, Z, Zhang, X, Zhang, P. | | 登録日 | 2023-02-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
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8HVT
 | | Structure of the human CLC-7/Ostm1 complex reveals a novel state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1, ... | | 著者 | Zhang, Z.X, Chen, L, He, J, She, J. | | 登録日 | 2022-12-27 | | 公開日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of the human CLC-7/Ostm1 complex reveals a novel state
To Be Published
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8GQU
 | | AK-42 inhibitor binding human ClC-2 TMD | | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | | 著者 | Wang, L. | | 登録日 | 2022-08-30 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
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8GAH
 | | CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
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8GA5
 | | CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
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8GA3
 | | CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
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8GA1
 | | CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
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8GA0
 | | CLC-ec1 E202Y at pH 4.5 100mM Cl Turn | | 分子名称: | H(+)/Cl(-) exchange transporter ClcA | | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | | 登録日 | 2023-02-22 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
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7XJA
 | | TMD masked refine map of human ClC-2 | | 分子名称: | Chloride channel protein 2 | | 著者 | Wang, L. | | 登録日 | 2022-04-15 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
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7XF5
 | | Full length human CLC-2 channel in apo state | | 分子名称: | Chloride channel protein 2 | | 著者 | Wang, L. | | 登録日 | 2022-04-01 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
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7XA9
 | | Structure of Arabidopsis thaliana CLCa | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | | 著者 | Ji, S, Jin, H, Kaiming, Z, Mingxing, W, Shanshan, L, Long, C. | | 登録日 | 2022-03-17 | | 公開日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket.
J.Biol.Chem., 299, 2023
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7RSB
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7RQ7
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7RP6
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7RP5
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7RO0
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