PDB: 165 件ウェブページステータス検索Chemie searchBIRD

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4HY5	Crystal structure of cIAP1 BIR3 bound to T3256336 分子名称: (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Dougan, D.R, Snell, G.P. 登録日 2012-11-13 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
4HY4	Crystal structure of cIAP1 BIR3 bound to T3170284 分子名称: (3S,8aR)-2-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Dougan, D.R, Mol, C.D, Snell, G.P. 登録日 2012-11-12 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.249 Å) 主引用文献 Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
4HY0	Crystal structure of XIAP BIR3 with T3256336 分子名称: (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, E3 ubiquitin-protein ligase XIAP, ZINC ION 著者 Snell, G.S, Dougan, D.R. 登録日 2012-11-12 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
4J47	Crystal structure of XIAP-BIR2 domain with SVPI bound 分子名称: E3 ubiquitin-protein ligase XIAP, PEPTIDE (SER-VAL-PRO-ILE), ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4J3Y	Crystal structure of XIAP-BIR2 domain 分子名称: E3 ubiquitin-protein ligase XIAP, ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4J48	Crystal structure of XIAP-BIR2 domain with AMRV bound 分子名称: E3 ubiquitin-protein ligase XIAP, GLYCEROL, PEPTIDE (ALA-MET-ARG-VAL), ... 著者 Gosu, R. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4J46	Crystal structure of XIAP-BIR2 domain with AVPI bound 分子名称: E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-VAL-PRO-ILE), ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4J44	Crystal structure of XIAP-BIR2 domain with AIAV bound 分子名称: E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-ILE-ALA-VAL), ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4J45	Crystal structure of XIAP-BIR2 domain with ATAA bound 分子名称: E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-THR-ALA-ALA), ZINC ION 著者 Lukacs, C.M, Janson, C.A. 登録日 2013-02-06 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr.,Sect.D, 69, 2013
4KMN	Structure of cIAP1-BIR3 and inhibitor 分子名称: (2S)-N-{(2R)-1-[(2R,4S)-2-{[6,6'-difluoro-3'-({(2R,4S)-4-hydroxy-1-[(2S)-2-{[(2S)-2-(methylamino)propanoyl]amino}butanoyl]pyrrolidin-2-yl}methyl)-1H,1'H-2,2'-biindol-3-yl]methyl}-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl}-2-(methylamino)propanamide, Baculoviral IAP repeat-containing protein 2, PHOSPHATE ION, ... 著者 Li, X, Wang, J, Condon, S.M, Shi, Y. 登録日 2013-05-08 公開日 2014-05-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.523 Å) 主引用文献 Structure of cIAP1-BIR3 and inhibitor To be Published
3SIQ	Crystal Structure of autoinhibited dIAP1-BIR1 domain 分子名称: Apoptosis 1 inhibitor, ZINC ION 著者 Li, X, Wang, J, Shi, Y. 登録日 2011-06-20 公開日 2011-08-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun, 2, 2011
3UEG	Crystal structure of human Survivin K62A mutant 分子名称: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 5, TETRAETHYLENE GLYCOL, ... 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
3UIK	crystal structure of human Survivin mutant K62Y/H80W in complex with H3(1-10) peptide 分子名称: Baculoviral IAP repeat-containing protein 5, ZINC ION, histone H3(1-10) peptide 著者 Du, J, Patel, D.J. 登録日 2011-11-04 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure, 20, 2012
3UEC	Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3. 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Baculoviral IAP repeat-containing protein 5, ... 著者 Niedzialkowska, E, Porebski, P.J, Cooper, D.R, Chruszcz, M, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
3UEI	Crystal structure of human Survivin E65A mutant 分子名称: Baculoviral IAP repeat-containing protein 5, ZINC ION 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell, 23, 2012
3UEF	Crystal structure of human Survivin bound to histone H3 (C2 space group). 分子名称: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 5, N-terminal fragment of histone H3, ... 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
3UIJ	Crystal structure of human Survivin K62Y/H80W mutant in complex with Smac/DIABLO(1-15) peptide 分子名称: Baculoviral IAP repeat-containing protein 5, Diablo homolog, mitochondrial, ... 著者 Du, J, Patel, D.J. 登録日 2011-11-04 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.705 Å) 主引用文献 Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure, 20, 2012
3UIH	crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide 分子名称: Baculoviral IAP repeat-containing protein 5, Diablo homolog, mitochondrial, ... 著者 Du, J, Patel, D.J. 登録日 2011-11-04 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure, 20, 2012
3UEH	Crystal structure of human Survivin H80A mutant 分子名称: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 5, DI(HYDROXYETHYL)ETHER, ... 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell, 23, 2012
3UIG	crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide 分子名称: Baculoviral IAP repeat-containing protein 5, T3 phosphorylated H3(1-15) peptide, ZINC ION 著者 Du, J, Patel, D.J. 登録日 2011-11-04 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure, 20, 2012
3UII	crystal structure of human Survivin in complex with H3(1-10) peptide 分子名称: Baculoviral IAP repeat-containing protein 5, ZINC ION, histone H3(1-10) peptide 著者 Du, J, Patel, D.J. 登録日 2011-11-04 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure, 20, 2012
3UEE	Crystal structure of human Survivin K62A mutant bound to N-terminal histone H3 分子名称: Baculoviral IAP repeat-containing protein 5, N-terminal fragment of histone H3, ZINC ION 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
3UED	Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3 (C2 space group). 分子名称: Baculoviral IAP repeat-containing protein 5, N-terminal fragment of histone H3, ZINC ION 著者 Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. 登録日 2011-10-30 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
3UW4	Crystal structure of cIAP1 BIR3 bound to GDC0152 分子名称: Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4, GDC0152, ... 著者 Maurer, B, Hymowitz, S. 登録日 2011-11-30 公開日 2012-02-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55, 2012
3UW5	Crystal structure of the BIR domain of MLIAP bound to GDC0152 分子名称: Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 4, GDC-0152, ... 著者 Maurer, B, Hymowitz, S.G. 登録日 2011-11-30 公開日 2012-02-22 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55, 2012

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