4HY5
Crystal structure of cIAP1 BIR3 bound to T3256336
Summary for 4HY5
Entry DOI | 10.2210/pdb4hy5/pdb |
Related | 4HY0 4HY4 |
Related PRD ID | PRD_001138 |
Descriptor | Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | iap family, bir repeats, card domain, ring-type zinc finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13490 |
Total number of polymer chains | 2 |
Total formula weight | 27931.91 |
Authors | Dougan, D.R.,Snell, G.P. (deposition date: 2012-11-13, release date: 2013-01-30, Last modification date: 2024-02-28) |
Primary citation | Hashimoto, K.,Saito, B.,Miyamoto, N.,Oguro, Y.,Tomita, D.,Shiokawa, Z.,Asano, M.,Kakei, H.,Taya, N.,Kawasaki, M.,Sumi, H.,Yabuki, M.,Iwai, K.,Yoshida, S.,Yoshimatsu, M.,Aoyama, K.,Kosugi, Y.,Kojima, T.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Imamura, S.,Ishikawa, T. Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56:1228-1246, 2013 Cited by PubMed: 23298277DOI: 10.1021/jm301674z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.752 Å) |
Structure validation
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