4HY4

Crystal structure of cIAP1 BIR3 bound to T3170284

Summary for 4HY4

Entry DOI	10.2210/pdb4hy4/pdb
Related PRD ID	PRD_001139
Descriptor	Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,8aR)-2-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total)
Functional Keywords	iap family, bir repeats, card domain, ring-type zinc finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q13490
Total number of polymer chains	2
Total formula weight	27767.90
Authors	Dougan, D.R.,Mol, C.D.,Snell, G.P. (deposition date: 2012-11-12, release date: 2013-01-30, Last modification date: 2024-02-28)
Primary citation	Hashimoto, K.,Saito, B.,Miyamoto, N.,Oguro, Y.,Tomita, D.,Shiokawa, Z.,Asano, M.,Kakei, H.,Taya, N.,Kawasaki, M.,Sumi, H.,Yabuki, M.,Iwai, K.,Yoshida, S.,Yoshimatsu, M.,Aoyama, K.,Kosugi, Y.,Kojima, T.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Imamura, S.,Ishikawa, T. Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56:1228-1246, 2013 Cited by PubMed: 23298277 DOI: 10.1021/jm301674z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.249 Å)

Structure validation