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2KU7	Solution structure of MLL1 PHD3-Cyp33 RRM chimeric protein Descriptor: MLL1 PHD3-Cyp33 RRM chimeric protein Authors: Song, J, Wang, Z, Patel, D. Deposit date: 2010-02-12 Release date: 2010-07-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
8KD5	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2 Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD3	Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD6	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3 Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD4	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1 Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD2	Rpd3S in complex with 187bp nucleosome Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD7	Rpd3S in complex with nucleosome with H3K36MLA modification and 167bp DNA Descriptor: 167bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-09 Release date: 2023-09-13 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
6G8R	SP140 PHD-Bromodomain complex with scFv Descriptor: 1,2-ETHANEDIOL, Nuclear body protein SP140, ZINC ION, ... Authors: Fairhead, M, Graslund, S, Strain-Damerell, C, Picaud, S.S, Pike, A.C.W, Pinkas, D.M, Wigren, E, Preger, C, Persson Lotsholm, H, Ossipova, E, Filippakopoulos, P, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2018-04-09 Release date: 2018-04-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.74 Å) Cite: SP140 PHD-Bromodomain complex with scFv To Be Published
6GUU	Structure of CHD5 PHD2 - tandem chromodomains Descriptor: Chromodomain-helicase-DNA-binding protein 5, ZINC ION Authors: Alt, A, Mancini, E.J. Deposit date: 2018-06-19 Release date: 2019-10-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structure of CHD5 PHD2 - tandem chromodomains To Be Published
7ZEZ	Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3 Descriptor: Histone H3, Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, MLL cleavage product N320, ... Authors: Blatter, M, Allain, F, Meylan, C. Deposit date: 2022-03-31 Release date: 2022-04-13 Last modified: 2023-05-03 Method: SOLUTION NMR Cite: RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEY	Complex Cyp33-RRM : MLL1-PHD3 Descriptor: MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION Authors: Blatter, M, Allain, F, Meylan, C. Deposit date: 2022-03-31 Release date: 2022-04-13 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
2FSA	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4ME2 bound state Descriptor: Histone H3(1-15)K4me2 peptide, ZINC ION, bromodomain PHD finger transcription factor Authors: Li, H, Patel, D.J. Deposit date: 2006-01-21 Release date: 2006-07-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
2F6J	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4me3 bound state Descriptor: ZINC ION, bromodomain PHD finger transcription factor, histone H3, ... Authors: Li, H, Patel, D.J. Deposit date: 2005-11-29 Release date: 2006-07-11 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
8BDY	Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 9 Descriptor: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ... Authors: Tassone, G, Pozzi, C, Palomba, T. Deposit date: 2022-10-20 Release date: 2022-12-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design. Int J Mol Sci, 23, 2022
8BD9	Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 10 Descriptor: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ... Authors: Tassone, G, Pozzi, C, Palomba, T. Deposit date: 2022-10-18 Release date: 2022-12-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design. Int J Mol Sci, 23, 2022
8BD8	Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 8 Descriptor: 1,3-dimethylbenzimidazol-2-one, CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ... Authors: Tassone, G, Pozzi, C, Palomba, T. Deposit date: 2022-10-18 Release date: 2022-12-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design. Int J Mol Sci, 23, 2022
2RI7	Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Nucleosome-remodeling factor subunit BPTF, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
3U5O	Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-22)K9me3K14acK18ac histone peptide Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2011-10-11 Release date: 2012-01-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A poised chromatin platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011
3U5P	Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac histone peptide Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2011-10-11 Release date: 2012-01-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A poised chromatin platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011
3U5N	Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-20)K9me3K14ac histone peptide Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2011-10-11 Release date: 2012-01-18 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A Poised Chromatin Platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011
3U5M	Crystal structure of TRIM33 PHD-Bromo in the free state Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2011-10-11 Release date: 2012-01-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.08 Å) Cite: A poised chromatin platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011
7VDV	The overall structure of human chromatin remodeling PBAF-nucleosome complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2, Actin, ... Authors: Chen, Z.C, Chen, K.J, Yuan, J.J. Deposit date: 2021-09-07 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605, 2022
8GXQ	PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... Authors: Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. Deposit date: 2022-09-21 Release date: 2022-11-02 Method: ELECTRON MICROSCOPY (5.04 Å) Cite: Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
8GXS	PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... Authors: Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. Deposit date: 2022-09-21 Release date: 2022-11-02 Method: ELECTRON MICROSCOPY (4.16 Å) Cite: Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
8I02	Cryo-EM structure of the SIN3S complex from S. pombe Descriptor: Chromatin modification-related protein eaf3, Cph1, Histone deacetylase clr6, ... Authors: Wang, C, Guo, Z, Zhan, X. Deposit date: 2023-01-10 Release date: 2023-05-03 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023

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