1IHV
| SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | HIV-1 INTEGRASE | 著者 | Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M. | 登録日 | 1995-05-12 | 公開日 | 1996-10-14 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry, 34, 1995
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1IHW
| SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES | 分子名称: | HIV-1 INTEGRASE | 著者 | Clore, G.M, Lodi, P.J, Ernst, J.A, Gronenborn, A.M. | 登録日 | 1995-05-12 | 公開日 | 1996-07-11 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry, 34, 1995
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1C0M
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1C1A
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1QMC
| C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures | 分子名称: | HIV-1 INTEGRASE | 著者 | Eijkelenboom, A.P.A.M, Sprangers, R, Hard, K, Puras Lutzke, R.A, Plasterk, R.H.A, Boelens, R, Kaptein, R. | 登録日 | 1999-09-27 | 公開日 | 1999-12-14 | 最終更新日 | 2015-10-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Refined Solution Structure of the C-Terminal DNA-Binding Domain of Human Immunovirus-1 Integrase. Proteins: Struct.,Funct., Genet., 36, 1999
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1C6V
| SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H) | 分子名称: | PROTEIN (SIU89134), PROTEIN (SIV INTEGRASE) | 著者 | Chen, Z, Yan, Y, Munshi, S, Li, Y, Zruygay-Murphy, J, Xu, B, Witmer, M, Felock, P, Wolfe, A, Sardana, V, Emini, E.A, Hazuda, D, Kuo, L.C. | 登録日 | 1999-12-21 | 公開日 | 2000-12-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform. J.Mol.Biol., 296, 2000
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1EX4
| HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, INTEGRASE | 著者 | Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M. | 登録日 | 2000-04-28 | 公開日 | 2000-06-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc.Natl.Acad.Sci.USA, 97, 2000
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4FW1
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4FW2
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5D7U
| Crystal structure of the C-terminal domain of MMTV integrase | 分子名称: | ISOPROPYL ALCOHOL, Pr160 | 著者 | Cook, N.J, Pye, V.E, Ballandras-Colas, A, Engelman, A, Cherepanov, P. | 登録日 | 2015-08-14 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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5EJK
| Crystal structure of the Rous sarcoma virus intasome | 分子名称: | DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*T)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... | 著者 | Yin, Z, Shi, K, Banerjee, S, Aihara, H. | 登録日 | 2015-11-02 | 公開日 | 2016-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of the Rous sarcoma virus intasome. Nature, 530, 2016
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3JCA
| Core model of the Mouse Mammary Tumor Virus intasome | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | 著者 | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | 登録日 | 2015-11-24 | 公開日 | 2016-02-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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5HOT
| Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | 分子名称: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | 著者 | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | 登録日 | 2016-01-19 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
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5TC2
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5U1C
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6RWO
| SIVrcm intasome (Q148H/G140S) in complex with bictegravir | 分子名称: | Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | 著者 | Cherepanov, P, Nans, A, Cook, N. | 登録日 | 2019-06-05 | 公開日 | 2020-02-05 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science, 367, 2020
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6RWL
| SIVrcm intasome | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), Pol protein, ... | 著者 | Cherepanov, P, Nans, A, Cook, N. | 登録日 | 2019-06-05 | 公開日 | 2020-02-05 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science, 367, 2020
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6RWN
| SIVrcm intasome in complex with dolutegravir | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | 著者 | Cherepanov, P, Nans, A, Cook, N. | 登録日 | 2019-06-05 | 公開日 | 2020-02-05 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science, 367, 2020
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6RWM
| SIVrcm intasome in complex with bictegravir | 分子名称: | Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | 著者 | Cherepanov, P, Nans, A, Cook, N. | 登録日 | 2019-06-05 | 公開日 | 2020-02-05 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science, 367, 2020
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6PUZ
| Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... | 著者 | Lyumkis, D, Jozwik, I.K, Passos, D. | 登録日 | 2019-07-18 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
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6PUY
| Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d) | 分子名称: | 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... | 著者 | Lyumkis, D, Jozwik, I.K, Passos, D. | 登録日 | 2019-07-18 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
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6PUT
| Structure of HIV cleaved synaptic complex (CSC) intasome bound with calcium | 分子名称: | CALCIUM ION, Chimeric Sso7d and HIV-1 integrase, ZINC ION, ... | 著者 | Lyumkis, D, Jozwik, I.K, Passos, D. | 登録日 | 2019-07-18 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
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6PUW
| Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC) | 分子名称: | Bictegravir, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... | 著者 | Lyumkis, D, Jozwik, I.K, Passos, D. | 登録日 | 2019-07-18 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
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6U8Q
| CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... | 著者 | Li, M, Chen, X, Craigie, R. | 登録日 | 2019-09-05 | 公開日 | 2020-02-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.67 Å) | 主引用文献 | A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies. J.Mol.Biol., 432, 2020
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6T6I
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