6PUZ
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f)
Summary for 6PUZ
Entry DOI | 10.2210/pdb6puz/pdb |
EMDB information | 20485 |
Descriptor | Chimeric Sso7d and HIV-1 integrase, viral DNA non-transferred strand, viral DNA transferred strand, ... (7 entities in total) |
Functional Keywords | integrase, intasome, transposition, viral protein-dna complex, viral protein/dna |
Biological source | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) More |
Total number of polymer chains | 6 |
Total formula weight | 185940.25 |
Authors | Lyumkis, D.,Jozwik, I.K.,Passos, D. (deposition date: 2019-07-18, release date: 2020-02-12, Last modification date: 2024-03-20) |
Primary citation | Passos, D.O.,Li, M.,Jozwik, I.K.,Zhao, X.Z.,Santos-Martins, D.,Yang, R.,Smith, S.J.,Jeon, Y.,Forli, S.,Hughes, S.H.,Burke Jr., T.R.,Craigie, R.,Lyumkis, D. Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367:810-814, 2020 Cited by PubMed: 32001521DOI: 10.1126/science.aay8015 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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