6PUY

Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d)

Summary for 6PUY

• Entry DOI: 10.2210/pdb6puy/pdb
• EMDB information: 20484
• Descriptor: Chimeric Sso7d and HIV-1 integrase, viral DNA non-transferred strand, viral DNA transferred strand, ... (7 entities in total)
• Functional Keywords: integrase, intasome, transposition, viral protein, viral protein-dna complex, viral protein/dna
• Biological source: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2); More
• Total number of polymer chains: 6
• Total formula weight: 185872.20

Authors

Lyumkis, D.,Jozwik, I.K.,Passos, D. (deposition date: 2019-07-18, release date: 2020-02-12, Last modification date: 2024-03-20)

• Primary citation: Passos, D.O.,Li, M.,Jozwik, I.K.,Zhao, X.Z.,Santos-Martins, D.,Yang, R.,Smith, S.J.,Jeon, Y.,Forli, S.,Hughes, S.H.,Burke Jr., T.R.,Craigie, R.,Lyumkis, D.; Structural basis for strand-transfer inhibitor binding to HIV intasomes.; Science, 367:810-814, 2020; PubMed: 32001521; DOI: 10.1126/science.aay8015

Experimental method

ELECTRON MICROSCOPY (2.8 Å)