PDB: 287 件ウェブページステータス検索Chemie searchBIRD

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5IZA	Protein-protein interaction 分子名称: ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein 著者 Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. 登録日 2016-03-25 公開日 2017-07-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
3TT9	Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant 分子名称: GLYCEROL, Plakophilin-2 著者 Schuetz, A, Roske, Y, Gerull, B, Heinemann, U. 登録日 2011-09-14 公開日 2012-08-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet, 5, 2012
3NMW	Crystal structure of armadillo repeats domain of APC 分子名称: APC variant protein, SULFATE ION 著者 Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. 登録日 2010-06-22 公開日 2011-07-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
6BW9	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1 分子名称: Importin subunit alpha-3, Protein W 著者 Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. 登録日 2017-12-14 公開日 2018-07-04 最終更新日 2023-03-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
4UAF	Importin alpha 1 delta IBB in complex with Influenza PB2 nuclear localization domain 分子名称: Importin subunit alpha-1, PHOSPHATE ION, Polymerase basic protein 2 著者 Pumroy, R.A, Cingolani, G. 登録日 2014-08-08 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7. Structure, 23, 2015
6IUA	Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D) 分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1 著者 Matsuura, Y. 登録日 2018-11-27 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochem. Biophys. Res. Commun., 510, 2019
5CTT	Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex 分子名称: Importin subunit alpha-1, Squamous cell carcinoma antigen recognized by T-cells 3 著者 Park, J.K, Kim, E.E. 登録日 2015-07-24 公開日 2016-04-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Nucleic Acids Res., 44, 2016
4YK6	Crystal structure of APC-ARM in complexed with Amer1-A4 分子名称: APC membrane recruitment protein 1, Adenomatous polyposis coli protein 著者 Zhang, Z, Xiao, Y, Wu, G. 登録日 2015-03-04 公開日 2016-03-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
4WV6	Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8 分子名称: 1,2-ETHANEDIOL, Importin subunit alpha-1, Transcription initiation factor TFIID subunit 8 著者 Trowitzsch, S. 登録日 2014-11-04 公開日 2015-01-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. Nat Commun, 6, 2015
6K06	Crystal structure of Importin-alpha and phosphomimetic GM130 分子名称: Importin subunit alpha-1, Peptide from Golgin subfamily A member 2 著者 Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. 登録日 2019-05-05 公開日 2019-10-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
4RXH	Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS 分子名称: Importin subunit alpha, Large T antigen 著者 Bernardes, N.E, Takeda, A.A.S, Fontes, M.R.M. 登録日 2014-12-11 公開日 2015-07-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7553 Å) 主引用文献 Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal. Plos One, 10, 2015
5Z8H	APC with an inhibitor 分子名称: Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor 著者 Zhang, J, Yang, X.Y, Song, K. 登録日 2018-01-31 公開日 2019-02-06 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 APC with an inhibitor To Be Published
8HE0	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type) 分子名称: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1 著者 Matsuura, Y. 登録日 2022-11-07 公開日 2023-02-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
4YI0	Structure of mouse importin a1 bound to Pom121NLS 分子名称: Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121 著者 Lokareddy, R.K, Cingolani, G. 登録日 2015-02-27 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.806 Å) 主引用文献 Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane To Be Published
7AFW	Beta-Catenin in complex with compound 6 分子名称: 3-[(2~{R})-4-methyl-5-oxidanylidene-2,3-dihydro-1,4-benzoxazepin-2-yl]benzenecarbonitrile, Catenin beta-1 著者 Boettcher, J, Kessler, D. 登録日 2020-09-21 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.814 Å) 主引用文献 Getting a Grip on the Undrugged: Targeting beta-Catenin with Fragment-Based Methods. Chemmedchem, 16, 2021
7RG1	Importin alpha2 in complex with MERS ORF4B H26A mutant 分子名称: Importin subunit alpha-1, ORF4b 著者 Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. 登録日 2021-07-14 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Importin alpha2 in complex with MERS ORF4B NLS H26A mutant To Be Published
4MZ6	Structure of importin-alpha: dUTPase S11E NLS mutant complex 分子名称: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 著者 Marfori, M, Rona, G, Vertessy, B.G, Kobe, B. 登録日 2013-09-29 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr.,Sect.D, 69, 2013
6IU7	Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type) 分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1 著者 Matsuura, Y. 登録日 2018-11-27 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochem. Biophys. Res. Commun., 510, 2019
8FUA	Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein NLS1 分子名称: Importin subunit alpha-1, Matrix protein 著者 Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. 登録日 2023-01-17 公開日 2023-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
4YJE	Crystal structure of APC-ARM in complexed with Amer1-A1 分子名称: APC membrane recruitment protein 1, Adenomatous polyposis coli protein 著者 Zhang, Z, Xiao, Y, Wu, G. 登録日 2015-03-03 公開日 2016-03-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
1JDH	CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4 分子名称: BETA-CATENIN, hTcf-4 著者 Graham, T.A, Ferkey, D.M, Mao, F, Kimelman, D, Xu, W. 登録日 2001-06-13 公開日 2001-12-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat.Struct.Biol., 8, 2001
8HE3	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751) 分子名称: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1, SULFATE ION 著者 Matsuura, Y. 登録日 2022-11-07 公開日 2023-02-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
5D5K	Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB 分子名称: Importin subunit alpha-1, Poly [ADP-ribose] polymerase 2 著者 Riccio, A.A, Cingolani, G, Pascal, J.M. 登録日 2015-08-10 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res., 44, 2016
5UMZ	Structure of TNRC6A NLS in complex with importin-alpha 分子名称: GLYCEROL, Importin subunit alpha-1, TNRC6A 著者 Chaston, J, Stewart, A.G, Christie, M. 登録日 2017-01-30 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE, 12, 2017
8HKW	Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal 分子名称: Importin subunit alpha-3, Peptide from TP53-binding protein 1 著者 Matsuura, Y. 登録日 2022-11-28 公開日 2022-12-21 最終更新日 2023-03-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data Brief, 47, 2023

 

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