Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8

Summary for 4WV6

DescriptorImportin subunit alpha-1, Transcription initiation factor TFIID subunit 8, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsnuclear import, armadillo repeats, nls, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P52292
Nucleus  Q7Z7C8
Total number of polymer chains3
Total molecular weight55077.77
Trowitzsch, S. (deposition date: 2014-11-04, release date: 2015-01-28)
Primary citation
Trowitzsch, S.,Viola, C.,Scheer, E.,Conic, S.,Chavant, V.,Fournier, M.,Papai, G.,Ebong, I.O.,Schaffitzel, C.,Zou, J.,Haffke, M.,Rappsilber, J.,Robinson, C.V.,Schultz, P.,Tora, L.,Berger, I.
Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Nat Commun, 6:6011-6011, 2015
PubMed: 25586196 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms7011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18020 0.5% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-12-02