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4WV6

Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0006606biological_processprotein import into nucleus
A0061608molecular_functionnuclear import signal receptor activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO A 601
ChainResidue
AGLN329
AARG366
APRO380
AHOH720
AHOH755

site_idAC2
Number of Residues3
Detailsbinding site for residue EDO A 602
ChainResidue
AASN375
AHOH911
AHOH1092

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 603
ChainResidue
AGLN93
AARG130
AHOH704
AHOH719
ASER88

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO A 604
ChainResidue
AASP325
AALA364
AGLY365
AARG366

site_idAC5
Number of Residues7
Detailsbinding site for residue EDO A 605
ChainResidue
AASP80
AALA96
AALA99
AGLU482
ALYS486
AHOH708
AHOH779

site_idAC6
Number of Residues3
Detailsbinding site for residue EDO A 606
ChainResidue
AVAL290
AHOH855
AHOH1065

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO A 607
ChainResidue
AGLN371
AVAL374
AGLN412
AHOH1104
AHOH1107

site_idAC8
Number of Residues3
Detailsbinding site for residue EDO A 608
ChainResidue
AGLN477
AHIS479
ATYR485

site_idAC9
Number of Residues3
Detailsbinding site for residue EDO A 609
ChainResidue
ALYS388
AALA389
AGLN394

site_idAD1
Number of Residues3
Detailsbinding site for residue EDO A 610
ChainResidue
ATHR324
AASP325
AGLU326

site_idAD2
Number of Residues2
Detailsbinding site for residue EDO A 611
ChainResidue
AGLU354
AHOH1099

site_idAD3
Number of Residues4
Detailsbinding site for residue EDO A 612
ChainResidue
ATHR345
AARG366
AGLN367
AASP368

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER62

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER490

226707

PDB entries from 2024-10-30

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