4WV6

Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006606	biological_process	protein import into nucleus
A	0061608	molecular_function	nuclear import signal receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 601

Chain	Residue
A	GLN329
A	ARG366
A	PRO380
A	HOH720
A	HOH755

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 602

Chain	Residue
A	ASN375
A	HOH911
A	HOH1092

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 603

Chain	Residue
A	GLN93
A	ARG130
A	HOH704
A	HOH719
A	SER88

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 604

Chain	Residue
A	ASP325
A	ALA364
A	GLY365
A	ARG366

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 605

Chain	Residue
A	ASP80
A	ALA96
A	ALA99
A	GLU482
A	LYS486
A	HOH708
A	HOH779

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 606

Chain	Residue
A	VAL290
A	HOH855
A	HOH1065

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 607

Chain	Residue
A	GLN371
A	VAL374
A	GLN412
A	HOH1104
A	HOH1107

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 608

Chain	Residue
A	GLN477
A	HIS479
A	TYR485

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 609

Chain	Residue
A	LYS388
A	ALA389
A	GLN394

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 610

Chain	Residue
A	THR324
A	ASP325
A	GLU326

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 611

Chain	Residue
A	GLU354
A	HOH1099

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 612

Chain	Residue
A	THR345
A	ARG366
A	GLN367
A	ASP368

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Repeat: {"description":"ARM 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	41
Details	Repeat: {"description":"ARM 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Repeat: {"description":"ARM 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Repeat: {"description":"ARM 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"ARM 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	39
Details	Repeat: {"description":"ARM 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Repeat: {"description":"ARM 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	Repeat: {"description":"ARM 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	39
Details	Repeat: {"description":"ARM 10; atypical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	96
Details	Region: {"description":"NLS binding site (major)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	88
Details	Region: {"description":"NLS binding site (minor)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---